PMID: 9160281Apr 1, 1997Paper

Role of lipid-induced changes in plasma membrane in the biophysical shunt theory of psychopathology

Medical Hypotheses
Y Naisberg, A Weizman

Abstract

The existence of a lipid factor that either causes faulty lipid metabolism or directly contributes to the emergence of a biophysical shunt in neuronal membrane ionic flow propagation is proposed. The neuronal membrane contains a remarkable amount of phospholipids, glycolipids and cholesterol. It is assumed that, under certain unfavorable intrinsic states, the plasma membrane's lipid order and composition and, consequently, its cholesterol-to-phospholipid ratio, may change. This, in turn, may significantly modify membrane fluidity, altering the essential physical properties in the affected portions of the membrane and causing a disarray in the adjacent ion channels, leading to the establishment of a biophysical shunt in a loop-like operation, forming the basis for a variety of mental disorders. The present model offers a diet-induced lipid correction for the relief of psychopathological problems.

References

Sep 1, 1992·Medical Hypotheses·M L BierenbaumT Watkins
Sep 1, 1991·Medical Hypotheses·P Singer, E Richter-Heinrich
Mar 1, 1991·Medical Hypotheses·B H Marshall
Oct 1, 1994·Schizophrenia Research·D F HorrobinK Vaddadi
Oct 1, 1994·Schizophrenia Research·J A StanleyR T Thompson
Nov 1, 1995·Medical Hypotheses·Y NaisbergA Weizman

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