Role of lipid mediators and control of lymphocyte responses in type 2 immunopathology

The Journal of Allergy and Clinical Immunology
Sachin K Samuchiwal, Joshua A Boyce

Abstract

Type 2 immunopathology is a cardinal feature of allergic diseases and involves cooperation between adaptive immunity and innate effector responses. Virtually all cell types relevant to this pathology generate leukotriene and/or prostaglandin mediators that derive from arachidonic acid, express receptors for such mediators, or both. Recent studies highlight prominent functions for these mediators in communication between the innate and adaptive immune systems, as well as amplification or suppression of type 2 effector responses. This review focuses on recent advances and insights, and highlights existing and potential therapeutic applications of drugs that target these mediators or their receptors, with a special emphasis on their regulation of the innate and adaptive lymphocytes relevant to type 2 immunopathology.

Citations

Aug 19, 2020·Essays in Biochemistry·Philip C Calder
Apr 30, 2019·Critical Reviews in Food Science and Nutrition·Rosina López-Fandiño
Apr 24, 2020·Science Translational Medicine·Marta de Los Reyes JiménezJulia Esser-von Bieren
Jun 14, 2019·Frontiers in Immunology·Philipp M HagemannZane Orinska
Mar 19, 2020·International Journal of Molecular Sciences·Kijeong LeeTae Hoon Kim
Apr 26, 2019·Frontiers in Immunology·Tiffany BoucheryNicola Harris
Sep 21, 2018·Frontiers in Immunology·Nincy Debeuf, Bart N Lambrecht
Dec 18, 2020·Frontiers in Immunology·Gabriel Mayoral AndradeEduardo Pérez-Campos
Jan 2, 2021·Biomolecules·Masaya KoganesawaBarbara Balestrieri
Apr 4, 2021·Journal of Fungi·Susana Ruiz MendozaAllan J Guimarães
May 10, 2021·The Journal of Allergy and Clinical Immunology·Kathleen R Bartemes, Hirohito Kita

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