PMID: 3438921Jan 1, 1987Paper

Role of lipid peroxidation in the toxicity of T-2 toxin

Toxicon : Official Journal of the International Society on Toxinology
A SchusterW Forth

Abstract

Recent reports suggest that lipid peroxidation may be involved in the toxicity of T-2 toxin. In the present study the influence of T-2 toxin on two parameters of lipid peroxidation was examined: the formation of thiobarbituric acid reactive material in isolated hepatocytes and liver homogenates from rats and ethane exhalation in vivo. In isolated hepatocytes there was no significant increase in thiobarbituric acid reactive material, neither after addition of T-2 toxin in vitro nor when the toxin had been applied to the rats 15 hr before preparation of hepatocytes. In liver homogenates the amount of thiobarbituric acid reactive material was increased up to 50% over the controls, depending on the dose of T-2 toxin. The increased values are difficult to interpret, because the extent of the increase depends on the method used for determination of thiobarbituric acid reactive material. Measuring another parameter of lipid peroxidation, i.e. ethane exhalation, there was no difference between the T-2 toxin treated rats and the controls whereas carbon tetrachloride treated rats exhaled high amounts of ethane. These results suggest that lipid peroxidation does not play a major role in T-2 toxin toxicity.

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Citations

May 23, 2012·Apoptosis : an International Journal on Programmed Cell Death·Haiqin FangShuangqing Peng
Mar 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B VilàA A Frohlich
Mar 29, 2001·Food Additives and Contaminants·P GuerreP Galtier
Nov 1, 1990·Food Additives and Contaminants·V A TutelyanJ T Kumpulainen
Mar 1, 1994·Zentralblatt für Veterinärmedizin. Reihe A·A F RizzoE Elovaara
Jun 16, 2009·Journal of Biochemical and Molecular Toxicology·Manjari ChaudhariP V Lakshmana Rao
Jan 17, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mona AgrawalP V Lakshmana Rao
Jan 21, 2015·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Marcela CapcarovaAlexander V Sirotkin
Aug 1, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T FrankicJ Salobir
Mar 28, 2020·PloS One·Shivasharanappa NayakwadiKanthesh M Basalingappa
Feb 5, 2021·Antioxidants·Alexandros MavrommatisKostas Feggeros

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