PMID: 26882029Feb 18, 2016Paper

Role of Liprins in the Regulation of Tumor Cell Motility and Invasion

Current Cancer Drug Targets
Sara Chiaretti, Ivan de Curtis

Abstract

Invasion leading to the formation of metastasis is one of the hallmarks of cancer. Analysis of different human cancers has led to the identification of the PPFIA1 gene encoding the protein liprin-α1, a possible player in cancer. The PPFIA1 gene is amplified in malignant tumors, including about 20% of breast cancers. Also the liprin-α1 protein is found overexpressed in tumors. Liprin-α1 belongs to the liprin family of cytosolic scaffold proteins that includes four liprin-α, two liprin-β members, and liprin-γ/kazrinE. In this review we will discuss the available evidence on the role of different members of the liprin family in distinct aspects of tumor cell migration and invasion. Evidence from in vitro studies indicates that the widely expressed liprin-α1 protein regulates the migration and invasion of human breast cancer cells. Liprin-α1 affects cell migration and invasion by regulating the organization of lamellipodia and invadopodia, two structures relevant to cell invasion. In the cell liprin-α1 forms a complex with liprin-β1, ERC1/ELKS and LL5 proteins, which localizes at the front of migrating cells and positively regulates lamellipodia stability, and integrin-mediated focal adhesions. On the other hand, liprin-β2 appears ...Continue Reading

Citations

Sep 24, 2016·Scientific Reports·Veronica AstroIvan de Curtis
Jul 18, 2019·Physiological Reviews·Michael BachmannBernhard Wehrle-Haller
May 8, 2018·Molecular Oncology·Varun MaturiAristidis Moustakas
Dec 29, 2017·Molecular Biology of the Cell·Natalya G DulyaninovaAnne R Bresnick
May 18, 2020·Matrix Biology : Journal of the International Society for Matrix Biology·Simone BuraschiAndrea Morrione
Oct 17, 2021·Oncogene·Henna PehkonenOuti Monni

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