Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease

Journal of Hepatology
Adel Hammoutene, Pierre-Emmanuel Rautou

Abstract

Non-alcoholic fatty liver disease (NAFLD) and its complications are an expanding health problem associated with the metabolic syndrome. Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells localized at the interface between the blood derived from the gut and the adipose tissue on the one side, and other liver cells on the other side. In physiological conditions, LSECs are gatekeepers of liver homeostasis. LSECs display anti-inflammatory and anti-fibrogenic properties by preventing Kupffer cell and hepatic stellate cell activation and regulating intrahepatic vascular resistance and portal pressure. This review focusses on changes occurring in LSECs in NAFLD and on their consequences on NAFLD progression and complications. Capillarization, namely the loss of LSEC fenestrae, and LSEC dysfunction, namely the loss of the ability of LSECs to generate vasodilator agents in response to increased shear stress both occur early in NAFLD. These LSEC changes favour steatosis development and set the stage for NAFLD progression. At the stage of non-alcoholic steatohepatitis, altered LSECs release inflammatory mediators and contribute to the recruitment of inflammatory cells, thus promoting liver injury and infla...Continue Reading

References

Nov 1, 1994·Gut·B SmedsrødA Geerts
Feb 11, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A M SeifalianB R Davidson
Oct 9, 1999·Transplantation·A M SeifalianB R Davidson
Aug 11, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·C A GunnettD D Heistad
Mar 1, 2002·Immunology and Cell Biology·Patricia F LalorDavid H Adams
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patricia F LalorDavid H Adams
Feb 15, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S D ChauhanA Ahluwalia
Jan 28, 2004·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Samia IjazAlexander M Seifalian
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Emilia IpIsabelle Leclercq
Feb 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sarah EdwardsDavid H Adams
Mar 30, 2005·The Journal of Nutrition·Wenjiang J FuGuoyao Wu
May 21, 2005·Seminars in Cell & Developmental Biology·Thomas Kietzmann, Agnes Görlach
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sarah N HilmerDavid G Le Couteur
Feb 7, 2006·Atherosclerosis·Victoria C CoggerDavid G Le Couteur
Aug 22, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hitoshi YoshijiHiroshi Fukui
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mitsuteru KitadeHiroshi Fukui
Oct 7, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Paola BrunDiego Martines
Oct 16, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sònia TuguesManuel Morales-Ruiz
Jan 22, 2008·Biochimica Et Biophysica Acta·Lorenz SchildGerburg Keilhoff
May 14, 2008·World Journal of Gastroenterology : WJG·Xiao-Dong HuangXi-Yan Zhan
May 20, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Geoff C FarrellR S McCuskey
May 20, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Zhen Fan Yang, Ronnie T P Poon
Jul 10, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laurie D DeleveYumei Guo
Sep 6, 2008·The American Journal of Pathology·Laurie D DeLeveRobert S McCuskey
Nov 6, 2008·Clinics in Liver Disease·Rebecca G Wells
Dec 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Valérie ParadisJacques Belghiti
Mar 26, 2009·European Journal of Gastroenterology & Hepatology·Giovanni TarantinoRaffaela Vecchione
May 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kerry-Lee MilnerJacob George
Jul 9, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fabio Marra, Cristiana Bertolani

❮ Previous
Next ❯

Citations

Jan 22, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Nynke SimonsMartijn C G J Brouwers
May 7, 2020·American Journal of Physiology. Cell Physiology·Xinghui Sun, Edward N Harris
Jul 22, 2020·Antioxidants & Redox Signaling·Sara PetrilloEmanuela Tolosano
Aug 22, 2020·Médecine sciences : M/S·Adel Hammoutene, Pierre-Emmanuel Rautou
Jul 25, 2019·Biomolecules·Edward N Harris, Fatima Cabral
Sep 29, 2020·Frontiers in Physiology·Alex L WilkinsonShishir Shetty
Apr 3, 2020·Scandinavian Journal of Gastroenterology·Søren MøllerFlemming Bendtsen
Jul 21, 2020·Exploration of Medicine·Marvin RyouGyorgy Baffy
Oct 17, 2019·International Journal of Molecular Sciences·Kaori Endo-Umeda, Makoto Makishima
May 19, 2020·Alimentary Pharmacology & Therapeutics·Ida Falk VillesenMette Juul Nielsen
Aug 28, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Reham M DawoodMostafa K El Awady
Nov 25, 2020·Archives of Pharmacal Research·Ji-Hak JeongYou Mie Lee
Jan 12, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zhenyu WangShaoling Lin
Dec 17, 2020·International Journal of Molecular Sciences·Aleksander J Nowak, Borna Relja
Dec 19, 2020·Nature Reviews. Gastroenterology & Hepatology·Albert GoughD Lansing Taylor
Jan 23, 2021·Biomedicines·David Højland Ipsen, Pernille Tveden-Nyborg
Feb 16, 2021·World Journal of Hepatology·Elias KouroumalisDimitrios N Samonakis
Nov 5, 2020·International Journal of Molecular Sciences·Tzu-Yin ChenKurt Ming-Chao Lin
Jan 29, 2021·World Journal of Gastroenterology : WJG·Xiaoqiang QiGuangfu Li
Feb 26, 2021·Nature Reviews. Cardiology·Nicolas RicardMichael Simons
Jan 22, 2021·The Journal of Clinical Investigation·Kunimaro FurutaSamar H Ibrahim
Mar 18, 2021·Molecular Biology Reports·Heming MaJunqi Niu
Mar 22, 2021·Angiogenesis·Philipp-Sebastian KochHellmut G Augustin
Apr 4, 2021·Journal of Clinical Medicine·Inês CoelhoCarlos Penha-Gonçalves
May 15, 2021·Cell·Rohit LoombaGerald I Shulman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.