Role of local and distant functional connectivity density in the development of minimal hepatic encephalopathy

Scientific Reports
Rongfeng QiGuang Ming Lu

Abstract

The progression of functional connectivity (FC) patterns from non-hepatic encephalopathy (non-HE) to minimal HE (MHE) is not well known. This resting-state functional magnetic resonance imaging (rs-fMRI) study investigated the evolution of intrinsic FC patterns from non-HE to MHE. A total of 103 cirrhotic patients (MHE, n = 34 and non-HE, n = 69) and 103 healthy controls underwent rs-fMRI scanning. Maps of distant and local FC density (dFCD and lFCD, respectively) were compared among MHE, non-HE, and healthy control groups. Decreased lFCD in anterior cingulate cortex, pre- and postcentral gyri, cuneus, lingual gyrus, and putamen was observed in both MHE and non-HE patients relative to controls. There was no difference in lFCD between MHE and non-HE groups. The latter showed decreased dFCD in inferior parietal lobule, cuneus, and medial frontal cortex relative to controls; however, MHE patients showed decreased dFCD in frontal and parietal cortices as well as increased dFCD in thalamus and caudate head relative to control and non-HE groups. Abnormal FCD values in some regions correlated with MHE patients' neuropsychological performance. In conclusion, lFCD and dFCD were perturbed in MHE. Impaired dFCD in regions within the corti...Continue Reading

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Citations

Oct 8, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ying LiZuojun Geng
Jan 28, 2018·Metabolic Brain Disease·Xiao Dong Zhang, Long Jiang Zhang
May 2, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Gaoyan ZhangShuangshuang Xie

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