Role of LPS-elicited signaling in triggering gastric mucosal inflammatory responses to H. pylori: modulatory effect of ghrelin

Inflammopharmacology
Bronislaw L Slomiany, Amalia Slomiany

Abstract

Infection with Helicobacter pylori is a primary culprit in the etiology of gastric disease, and its cell-wall lipopolysaccharide (LPS) is recognized as a potent endotoxin responsible for triggering a pattern of the mucosal inflammatory responses. The engagement by the LPS of gastric mucosal Toll-like receptor 4 (TLR4) leads to initiation of signal transduction events characterized by the activation of mitogen-activated protein kinase (MAPK) cascade, induction of phosphoinositide-specific phospholipase C (PLC)/protein kinase C (PKC)/phosphatidylinositol 3-kinase (PI3K) pathway, and up-regulation in Src/Akt. These signaling events in turn exert their influence over H. pylori-elicited excessive generation of NO and PGE2 caused by the disturbances in nitric oxide synthase and cyclooxygenase isozyme systems, increase in epidermal growth factor receptor transactivation, and the induction in matrix metalloproteinase-9 (MMP-9) release. Interestingly, the extent of gastric mucosal inflammatory response to H. pylori is influenced by a peptide hormone, ghrelin, the action of which relays on the growth hormone secretagogue receptor type 1a (GHS-R1a)-mediated mobilization of G-protein dependent transduction pathways. Yet, the signals trigge...Continue Reading

References

May 15, 1992·Biochemical and Biophysical Research Communications·Y H LiauB L Slomiany
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·J E Crabtree
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·M Stolte, S Eidt
Mar 1, 1997·Scandinavian Journal of Gastroenterology·J PiotrowskiB L Slomiany
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E CarioD K Podolsky
Feb 19, 2000·Current Opinion in Cell Biology·B L GoodeG Barnes
Mar 2, 2002·Journal of Biochemistry·Makoto Murakami, Ichiro Kudo
Jul 30, 2003·The Journal of Biological Chemistry·Sudipto DasWonhwa Cho
Nov 19, 2003·Molecular and Cellular Biochemistry·Suman Kumar DharGauranga Mukhopadhyay
May 26, 2004·Journal of Cell Science·William C Sessa
May 29, 2004·Helicobacter·Philip J BerginQuiding-Järbrink Marianne
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Niki L ReynaertYvonne M W Janssen-Heininger
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Sep 1, 2004·Cellular Signalling·Mona JohannessenUgo Moens
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Hiroyuki OsawaKentaro Sugano
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chang-Hoon WooJae-Hong Kim
Feb 3, 2005·Cell Research·Tyler Zarubin, Jiahuai Han
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Riku KorhonenEeva Moilanen
Aug 30, 2005·Cellular Signalling·Marit Pedersen DelghandiUgo Moens
Nov 16, 2005·The Journal of Biological Chemistry·Phillip A ErwinThomas Michel
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anatoly V GrishinHenri R Ford
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Mar 23, 2006·Annual Review of Immunology·Bruce BeutlerKasper Hoebe
Jun 14, 2006·American Journal of Physiology. Cell Physiology·Haruhiko OhtsuSatoru Eguchi
Jul 19, 2006·Clinical Microbiology Reviews·Johannes G KustersErnst J Kuipers
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yeon-Joo KangWilliam L Smith
Dec 22, 2006·Nature Reviews. Molecular Cell Biology·Neil D Perkins
Jan 16, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Myungsoo JooJohn W Christman
Feb 6, 2007·Seminars in Immunology·Taro Kawai, Shizuo Akira

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Citations

Mar 31, 2018·Minerva gastroenterologica e dietologica·Gianenrico RizzattiAntonio Gasbarrini
Feb 3, 2018·World Journal of Gastroenterology : WJG·Paula ManteroCinthia Gabriela Goldman
Sep 29, 2019·World Journal of Gastroenterology : WJG·Huan LiXiao-Ming Liu
Jun 18, 2020·World Journal of Clinical Cases·Ze-Yu WuBing Chang
Mar 2, 2019·Inflammopharmacology·Bronislaw L Slomiany, Amalia Slomiany
May 2, 2018·World Journal of Gastroenterology : WJG·Kosuke MinagaMasatoshi Kudo
Jul 14, 2020·World Journal of Gastroenterology : WJG·Aida KamalianAmir Hossein Abdolghaffari
Jan 8, 2020·International Journal of Molecular Sciences·Chien-Chung YangChuen-Mao Yang
Dec 10, 2020·International Journal of Molecular Sciences·Rita PolitoMaria Rosaria Rizzo
Jan 23, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Natasha K LeeuwendaalHarriët Schellekens

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Methods Mentioned

BETA
nuclear translocation
GTPase
nucleotide exchange
GTPases
acetylation

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