Role of luteinizing hormone in regulating luteal function in ruminants

Journal of Animal Science
G D NiswenderT M Nett

Abstract

The technique of hypothalamic-pituitary stalk-disconnection was used to reinvestigate the roles of luteinizing hormone (LH) and prolactin in the regulation of luteal function in ewes. Stalk-disconnection was performed on d 5 of the estrous cycle and ewes were administered either saline (control), LH at 40 micrograms at 4-h intervals, 2 mg of alpha-ergocryptine at 12-h intervals or both LH and ergocryptine. The treatment regimen for LH was designed to mimic luteal phase concentrations of this hormone. Blood samples were collected from all stalk-disconnected and 6 sham-disconnected ewes at 4-h intervals beginning at 0600 h on the day of surgery for determination of serum concentrations of prolactin, cortisol and progesterone. Corpora lutea were collected from control ewes on d 5 of the estrous cycle and from the stalk-disconnected and sham-disconnected ewes on d 12 of the cycle. The luteal tissue was weighed, a slice taken for morphometric analysis of cell numbers, sizes and types and luteal progesterone content was determined. The weight and progesterone content of corpora lutea collected from stalk-disconnected ewes were similar to those observed in control ewes on d 5 of the cycle but less (P less than .05) than those in contr...Continue Reading

Citations

Jan 5, 2000·Physiological Reviews·G D NiswenderE W McIntush
Apr 13, 2010·Prostaglandins & Other Lipid Mediators·Y S WeemsC W Weems

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