Role of lymph node dissection during radical nephroureterectomy for upper urinary tract urothelial cancer: multi-institutional large retrospective study JCOG1110A

World Journal of Urology
Junichi InokuchiSeiji Naito

Abstract

To evaluate the impact of lymph node dissection (LND) on clinical outcome during radical nephroureterectomy (RNU) for patients with upper urinary tract urothelial cancer (UTUC). We, the Urologic Oncology Study Group of the Japan Clinical Oncology Group (JCOG), retrospectively collected data from patients with non-metastatic UTUC who underwent RNU in 30 centers in 1995-2009. Ineligible patients and patients with previous and/or synchronous bladder cancer were excluded, and the remaining 2037 patients were analyzed. We compared overall and cancer-specific mortality between patients who underwent LND (LND group) and those without LND (no-LND group). Among 2037 patients, LND was performed in 1046 (51.4%) patients, and 223 (10.9%) patients had pathological node-positive (pN+) disease. All-cause mortality was observed in 503 patients (24.7%) during follow-up (median 45.8 months), including 363 patients (17.8%) who died of UTUC. Patients with pN+ disease showed significantly shorter overall survival (OS) compared with pN0 patients, and the estimated 5-year OS for pN+ patients was 30%. Older age, ≥cT3, and clinical node-positive disease were found as preoperative predictors for pN+ disease by multivariate analysis. In the comparison of...Continue Reading

References

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Citations

Aug 11, 2019·Journal of Clinical Medicine·Igor DuquesneEvanguelos Xylinas
Nov 17, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Jun MikiShin Egawa
Dec 8, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Junichi InokuchiUNKNOWN Urologic Oncology Study Group of the Japan Clinical Oncology Group (JCOG)
Dec 20, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Sebastiano NazzaniPierre I Karakiewicz
Mar 26, 2021·Arab Journal of Urology·Vinson Wai-Shun ChanJeremy Yuen-Chun Teoh

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