Role of lymphotoxin alpha in T-cell responses during an acute viral infection

Journal of Virology
M SureshRafi Ahmed

Abstract

The importance of lymphotoxin alpha (LTalpha) in lymphoid organogenesis is well established. Although LTalpha has been implicated in the pathogenesis of T-cell-mediated immunopathologies, the requirement for LTalpha in T-cell activation and effector function in vivo is not well understood. To determine the role of LTalpha in T-cell activation in vivo, we compared the generation of antigen-specific T-cell responses between wild type (+/+) and LTalpha-deficient (LTalpha(-/-)) mice during an acute infection with lymphocytic choriomeningitis virus (LCMV). Our studies showed that LCMV-infected LTalpha(-/-) mice had a profound impairment in the activation and expansion of virus-specific CD8 T cells in the spleen, as determined by cytotoxicity assays, intracellular staining for gamma interferon, and staining with major histocompatibility complex class I tetramers. Further, the nonlymphoid organs of LTalpha(-/-) mice also contained substantially lower number of LCMV-specific CD8 T cells than those of +/+ mice. Greatly reduced virus-specific CD8 T-cell responses in LTalpha(-/-) mice led to a defect in LCMV clearance from the tissues. In comparison to that in +/+ mice, the activation of LCMV-specific CD4 T cells was also significantly at...Continue Reading

References

Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·C M WalshW R Clark
Jan 1, 1995·Current Topics in Microbiology and Immunology·C F WareJ L Browning
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·H von Boehmer
Oct 23, 1997·The Journal of Experimental Medicine·W E SuenN H Ruddle
Dec 22, 1998·The Journal of Experimental Medicine·A J ZajacR Ahmed
Jun 8, 1999·Annual Review of Immunology·Y X Fu, D D Chaplin
Jul 16, 1999·Virology·D P BergerM B Oldstone
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·U KumaraguruB T Rouse
Feb 24, 2001·The Journal of Experimental Medicine·D R RoachW J Britton

❮ Previous
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Citations

May 15, 2007·Immunologic Research·Yanhui XuLieping Chen
Sep 15, 2005·Cancer Immunology, Immunotherapy : CII·David SchramaJürgen C Becker
Jul 3, 2007·Cancer Immunology, Immunotherapy : CII·David SchramaJürgen C Becker
Sep 2, 2004·Nature Medicine·Max Corbett, Jean-Pierre Kraehenbuhl
Apr 10, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shahram Salek-Ardakani, Michael Croft
Apr 13, 2013·Science·John R TeijaroMichael B A Oldstone
Jun 3, 2000·Annual Review of Immunology·J T HartyD W White
Mar 18, 2005·Annual Review of Immunology·Carl F Ware
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·Vanja Lazarevic, JoAnne Flynn
Feb 24, 2012·PLoS Pathogens·Jeremy A SullivanM Suresh
Nov 9, 2004·Advances in Virus Research·J Lindsay WhittonJason K Whitmire
May 18, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomoki MaedaToshiaki Miyadai
Jul 15, 2006·European Journal of Immunology·Tobias JuntRolf M Zinkernagel
Apr 15, 2008·American Journal of Reproductive Immunology : AJRI·Natasa Strbo, Eckhard R Podack
Sep 17, 2003·Nature Reviews. Immunology·Jennifer L Gommerman, Jeffrey L Browning
Apr 11, 2012·Nature Reviews. Immunology·Leslie Summers deLuca, Jennifer L Gommerman
Oct 25, 2011·Immunological Reviews·Jennifer L Gommerman, Leslie Summers deLuca
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason K WhitmireRafi Ahmed
Jun 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xilai DingHongyu Deng
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Theresa A BanksCarl F Ware
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Frances E LundTroy D Randall
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anju SinghM Suresh
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer LoutenChristine A Biron
Sep 14, 2016·Cytokine·Ekaterina P KorolevaAlexei V Tumanov
Nov 18, 2004·Immunological Reviews·Kirsten SchneiderCarl F Ware

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