Jan 1, 1976

Role of lysyl-tRNA in the regulation of lysine biosynthesis in Escherichia coli K12

Biochimie
E BoyJ C Patte

Abstract

A mutant of lysyl-tRNA synthetase has been isolated in Escherichia coli K12. With this strain the Kmapp for lysine is 25 fold higher than with the parental strain. The percentage of charged tRNAlys in vivo is only 7 per cent (as against 65 per cent with HFR H). Under these conditions no derepression of synthesis is observed for three lysine biosynthetic enzymes (AK III, ASA-dehydrogenase, DAP-decarboxylase) ; a partial derepression is obtained in the case of the dhdp-reductase. Thus lysyl-tRNA does not act as the only corepressor molecule in the lysine regulon.

  • References3
  • Citations7

References

Mentioned in this Paper

Alkalescens-Dispar Group
Enzymes, antithrombotic
MT-TA gene
KARS gene
Oxidase
Escherichia coli K12
Triplet Codon-amino Acid Adaptor Activity
Transfer RNA
Carboxy-Lyases
Lysine Biosynthesis Pathway

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