PMID: 9191876May 1, 1997Paper

Role of macrophage-colony-stimulating factor in regulating the accumulation and phenotype of tumor-associated macrophages

Cancer Immunology, Immunotherapy : CII
S T DoughertyG J Dougherty

Abstract

In order to better define the role played by tumor-cell-derived macrophage-colony-stimulating factor (M-CSF) in regulating the recruitment and phenotype of tumor-associated macrophages, Polyoma large T-transformed fibroblastoid cell lines, derived from M-CSF-deficient osteopetrotic op/op mice and their phenotypically normal op/+ littermate controls, were inoculated into SCID (severe combined immunodeficiency) recipients and both the proportion and phenotype of the macrophages present within the tumors generated were determined. The results obtained indicate that, although tumors derived from M-CSF-deficient and M-CSF-producing tumor cell inoculate contain a similar proportion of macrophages, the macrophages isolated from tumors lacking M-CSF appear morphologically less mature and express lower levels of interleukin 1 beta, tumor necrosis factor alpha and FcR gamma II mRNA. Taken together, these data suggest that, although M-CSF does not appear to play a critical role in determining the macrophage content of these tumors, it does play a role in modulating the phenotype, and potentially the functional activity of the macrophages present within the tumor microenvironment.

Citations

Dec 13, 2005·Current Opinion in Immunology·Violeta Chitu, E Richard Stanley
Jul 26, 2006·Journal of Leukocyte Biology·Chrystelle LamagnaBeat A Imhof
Oct 26, 2011·Immunology and Cell Biology·Matthew J SweetDavid P Fairlie
Feb 9, 2012·British Journal of Clinical Pharmacology·Inge De MeyerGuido R Y De Meyer
Mar 3, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrew I U ShearnPhilippe Lesnik
Dec 7, 2018·Bioinformatics·Andrew PartonSteven Watterson
May 17, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·John E Mindur, Filip K Swirski
Mar 25, 2015·The Journal of Experimental Medicine·Partha DuttaMatthias Nahrendorf
Dec 28, 2018·Cardiovascular Research·Annas Al-ShareaAndrew J Murphy
Oct 28, 2019·International Journal of Molecular Sciences·Beatriz Herrero-FernandezJose Maria Gonzalez-Granado
Sep 16, 2009·The Journal of Experimental Medicine·Su-Ning ZhuMyron I Cybulsky

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