PMID: 6159508Oct 11, 1980Paper

Role of macrophage-dependent determinant selection in induction phase of streptococcal carditis

Lancet
G A Dos Reis, M A Barcinski

Abstract

A genetically controlled antigen-presentation function in macrophages is proposed to explain the induction phase of streptococcal carditis. Antigenic determinants in strains of beta-haemolytic streptococci causing rheumatic fever are selected by macrophages, through the operation of immune response (Ir) genes, to be presented to T lymphocytes. Cross-reactivity between the selected determinants and heart tissue components generates clones of autoreactive T cells. Autoimmunity will develop if, coincidental with the presentation of the relevant antigenic determinant, regulation of T-cell production is disturbed. This hypothesis explains the capacity of different strains of streptococcus to produce rheumatic fever and also the variability in host susceptibility to the disease.

References

Aug 1, 1977·The Journal of Experimental Medicine·L C YangE N Fox

❮ Previous
Next ❯

Citations

Sep 1, 1990·Indian Journal of Pediatrics·K S ReddyN K Mehra
Nov 1, 1982·Indian Journal of Pediatrics·K S ReddyM L Bhatia
Feb 1, 1986·Arthritis and Rheumatism·G HusbyC Butler
Jan 1, 1989·Clinical Cardiology·R BhatiaM L Bhatia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.