PMID: 9189083Jun 1, 1997Paper

Role of macrophage overactivation in the development of acute pancreatic injury in rats

The British Journal of Surgery
R AnderssonX D Wang

Abstract

An increase in systemic inflammatory mediators from stimulated leucocytes and macrophages has been noted during acute pancreatitis. The role of cytolytic inflammatory macrophages and potential mechanisms in the development of acute pancreatic injury and endothelial barrier dysfunction are less well defined. Rats were challenged by an intraperitoneal injection of cytolytic or non-cytolytic inflammatory macrophage stimulators at various concentrations. The effects of oxygen free radicals, prostaglandin and extracellular calcium influx on macrophage-associated pancreatic endothelial compromise, measured by pancreatic intravascular plasma volume, pancreatic interstitial fluid volume, and the pancreatic extravascular human serum albumin distribution volume, were explored. Zymosan-induced overactivation of cytolytic inflammatory macrophages resulted in the development of acute pancreatic endothelial dysfunction in a dose- and time-dependent pattern. An increase in pancreatic water content and interstitial fluid volume was observed following a higher dose (0.5 mg/g) of concanavalin A without alteration in plasma lipase level, while thioglycollate medium did not compromise pancreatic endothelial barrier function. Oxygen free radicals, ...Continue Reading

References

Dec 1, 1978·The Journal of Experimental Medicine·J Schnyder, M Baggiolini
May 1, 1991·Der Radiologe·R Köster
Jun 1, 1990·The Journal of Surgical Research·A J BilchikI M Modlin
Jan 1, 1986·Pancreas·J R Malagelada
Feb 28, 1974·The New England Journal of Medicine·J M Acosta, C L Ledesma
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Nov 1, 1993·Pancreas·G Klöppel, B Maillet

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