Role of macrophages and colony-stimulating factor-1 in murine antiglomerular basement membrane glomerulonephritis.

Journal of the American Society of Nephrology : JASN
J NeugartenD Schlondorff

Abstract

Macrophages have been shown to mediate glomerular injury in antiglomerular basement membrane (anti-GBM) glomerulonephritis in rats and rabbits. To evaluate the role of macrophages and the macrophage-related cytokines, colony stimulating factor-1 (CSF-1), monocyte chemoattractant protein-1 (MCP-1) and RANTES, accelerated anti-GBM nephritis was studied in op/op mutant mice, which lack CSF-1 and are severely macrophage deficient, and in heterozygous op/+ control mice. Observations were made 24 h and 3 days after the injection of rabbit anti-mouse GBM antibody in mice preimmunized with rabbit immunoglobulin G. Proteinuria rose progressively in both groups but did not differ between them (urine protein/creatinine ratio at 3 days: 1.01 +/- 0.38 in op/op versus 1.45 +/- 0.43 in op/+; P, not significant). In both op/op and op/+ mice, anti-GBM nephritis was associated with renal expression of mRNA for RANTES and MCP-1 and barely detectable levels of mRNA for CSF-1. In contrast, these cytokines were not expressed in sham-injected mice. Morphologic lesions appeared earlier in op/op mice but were comparable by Day 3. Glomerular injury consisted of capillary thrombosis and endothelial cell damage associated with mild to moderate leukocyte i...Continue Reading

Citations

Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E SchaddeD Schlöndorff
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M KretzlerH Holthöfer
Jul 20, 1999·Kidney International·S SegererD Schlöndorff
Nov 30, 1999·Journal of the American Society of Nephrology : JASN·B BanasD Schlöndorff
Jan 5, 2000·Journal of the American Society of Nephrology : JASN·Stephan SegererDetlef Schlöndorff
Apr 12, 2001·European Journal of Immunology·N S SheerinS H Sacks
Apr 24, 2001·Journal of the American Society of Nephrology : JASN·Hans-Joachim AndersDetlef Schlöndorff
Jul 28, 2001·Kidney International·B H Rovin
Feb 22, 2003·Journal of the American Society of Nephrology : JASN·Hitomi KawanoHiroshi Iwao
May 13, 1999·International Journal of Experimental Pathology·B RyffelM Le Hir
Mar 13, 2003·Kidney International·Hans-Joachim AndersDetlef Schlöndorff
Dec 15, 1996·Journal of Neuroscience Research·R S GhirnikarL F Eng
Apr 29, 1998·Kidney International·V CattellF Y Liew
Mar 1, 1997·Kidney International·D SchlöndorffB Banas
Dec 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·U O Wenzel, H E Abboud
Jul 10, 2009·American Journal of Physiology. Renal Physiology·Pu Duann, Elias A Lianos

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