PMID: 8602664Feb 1, 1996Paper

Role of magnesium sulfate in postoperative analgesia

Anesthesiology
M R TramerK Rifat

Abstract

N-methyl-D-aspartate antagonists may play a role in the prevention of pain. An assessment was made of the effect of the physiologic N-methyl-D-aspartate antagonist magnesium on analgesic requirements, pain, comfort, and quality of sleep in the postoperative period. In a randomized, double-blind study, 42 patients undergoing elective abdominal hysterectomy with general anesthesia received 20% magnesium sulfate or saline (control) 15 ml intravenously before start of surgery and 2.5 ml/h for the next 20 h. Postoperative morphine requirement was assessed for 48 h using patient-controlled analgesia. Maximum expiratory flow (peak flow), pain at rest and during peak flow, and discomfort were evaluated up to the 48th postoperative hour, and 1 week and 1 month after surgery. Insomnia was evaluated after the first and second postoperative nights. Compared to control subjects, magnesium-treated patients consumed less morphine during the first 48h (P<0.03), which was most pronounced during the first 6 h (P<0.004), and experienced less discomfort during the first and second postoperative days (P<0.05-0.005). The magnesium-treated group revealed no change in postoperative sleeping patterns when compared to preoperative patterns. Control pati...Continue Reading

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Citations

Aug 29, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Laurent Dubé, Jean-Claude Granry
Jan 1, 1998·European Psychiatry : the Journal of the Association of European Psychiatrists·J WidmerP Bovier
Oct 24, 2002·British Journal of Anaesthesia·S BrillP P Di Vadi
Aug 16, 2013·Obstetrical & Gynecological Survey·Laleh AzariShelby E Osborne
Apr 16, 1998·Anesthesia and Analgesia·H ChoeH S Song
Jul 14, 1998·Anesthesia and Analgesia·H KoinigN Mayer
Mar 29, 2000·Anesthesia and Analgesia·J S KroinA D Ivankovich
Aug 29, 2002·Anesthesia and Analgesia·Dilek MemişZafer Pamukçu
Aug 29, 2002·Anesthesia and Analgesia·Asokumar BuvanendranKenneth J Tuman
Mar 23, 2005·Anesthesia and Analgesia·Alparslan TuranZafer Pamukçu
May 22, 2007·Anesthesia and Analgesia·Christopher LysakowskiMartin R Tramèr
Mar 7, 2007·CNS Drugs·Srinivas Pyati, Tong J Gan
Oct 22, 2002·Journal of the American Veterinary Medical Association·Simon T Kudnig, Khursheed Mama
Oct 1, 2010·Indian Journal of Anaesthesia·Tanmoy GhatakVinod Kumar Bhatia
Jan 1, 2011·International Journal of Pharmaceutical Investigation·V Di StefanoMg Sidoti
Feb 22, 2012·Journal of Anaesthesiology, Clinical Pharmacology·Mahendra KumarAk Sethi
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Jul 17, 2009·Current Opinion in Anaesthesiology·Asokumar Buvanendran, Jeffrey S Kroin
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Jan 19, 2010·Pharmacological Reports : PR·Magdalena BujalskaStanisław W Gumułka
Nov 28, 2012·Journal of Pain and Symptom Management·Vincent CrosbyAndrew Wilcock

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