Role of mature sphingolipids in yeast: new tools

Molecular Microbiology
Andreas Conzelmann

Abstract

Sphingolipids of yeast have been described as being important for numerous cell biological phenomena such as heat resistance, endocytosis, stress resistance and many others. The genetic or pharmacological elimination of specific features or entire classes of sphingolipids has pinpointed specific sphingolipids as pivotal regulators in many processes. The report by Epstein et al. adds two new tools for such studies: a strain being completely resistant to aureobasidin A, a specific inhibitor of inositol phosphorylceramide synthase and a second strain where this synthase is deleted. The resulting phenotypes advocate new roles of complex sphingolipids in cytokinesis, lipid droplet biogenesis and cell survival.

References

Oct 23, 1997·The Journal of Biological Chemistry·J D SabaY A Hannun
Sep 29, 2004·The Journal of Biological Chemistry·Morihisa FujitaYoshifumi Jigami
Mar 3, 2005·The Journal of Biological Chemistry·Takafumi KobayashiYasunori Kozutsumi
Sep 22, 2006·The Biochemical Journal·Vanessa CerantolaAndreas Conzelmann
Apr 24, 2007·The Journal of Biological Chemistry·Fikadu Geta TafesseJoost C M Holthuis
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Françoise M RoelantsJeremy Thorner
Jun 8, 2010·Nature Structural & Molecular Biology·Pablo S AguilarTobias C Walther
Oct 6, 2010·Advances in Experimental Medicine and Biology·Robert C Dickson
Oct 19, 2010·Journal of Molecular Biology·Aurélie BertinEva Nogales
Nov 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Françoise M RoelantsJeremy Thorner
May 24, 2012·Molecular Microbiology·Sharon EpsteinHoward Riezman

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