Role of mean platelet volume and ischemia modified albumin in evaluation of oxidative stress and its association with postnatal complications in infants of diabetic mothers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Lamiaa MohsenNermine Magdi Riad

Abstract

Gestational diabetes mellitus (GDM) is accompanied by increased oxidative stress, causing many complications to pregnant women and their newborns. We aimed to determine cord blood levels of mean platelet volume (MPV) and ischemia modified albumin (IMA) as a reflection of oxidative stress in babies born to mothers suffering from GDM. Eighty pregnant women were enrolled in the study. They were divided into two groups: 40 with GDM and 40 healthy matched controls. Each group included twenty giving birth by normal vaginal delivery (NVD) and twenty by cesarean section (C.S). The MPV and the IMA levels were measured. Complete physical examination of babies was done at birth and follow up at age of one week. Comparison between infants of diabetic mothers and of healthy mothers showed statistically significant difference in the levels of MPV (p < .001) and IMA (p = .001). Also, there was a statistically significant difference in MPV (p < .001) and IMA (p = .005) between diabetic females who gave birth by NVD and C.S. ROC curve analysis showed that IMA and MPV variables were related to the postnatal outcomes. MPV and IMA are useful markers of the potential oxidative stress in infants of diabetic mothers and of postnatal complications.

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Citations

Apr 6, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eser ColakSevsen Kulaksızoglu
Apr 6, 2020·Frontiers of Medicine·Pengju ZhangYuanyuan Zhang
Nov 2, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yesim Bayoglu TekinAdnan Yilmaz

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