Role of mechanical factors in cortical folding development

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Mir Jalil RazaviXianqiao Wang

Abstract

Deciphering mysteries of the structure-function relationship in cortical folding has emerged as the cynosure of recent research on brain. Understanding the mechanism of convolution patterns can provide useful insight into the normal and pathological brain function. However, despite decades of speculation and endeavors the underlying mechanism of the brain folding process remains poorly understood. This paper focuses on the three-dimensional morphological patterns of a developing brain under different tissue specification assumptions via theoretical analyses, computational modeling, and experiment verifications. The living human brain is modeled with a soft structure having outer cortex and inner core to investigate the brain development. Analytical interpretations of differential growth of the brain model provide preliminary insight into the critical growth ratio for instability and crease formation of the developing brain followed by computational modeling as a way to offer clues for brain's postbuckling morphology. Especially, tissue geometry, growth ratio, and material properties of the cortex are explored as the most determinant parameters to control the morphogenesis of a growing brain model. As indicated in results, compr...Continue Reading

References

Oct 24, 2015·ACS Nano·Karson BrooksJason Locklin
Nov 18, 2016·Scientific Reports·Tuo ZhangXianqiao Wang
Mar 9, 2017·Journal of Computational Neuroscience·Tuo ZhangXianqiao Wang
Jul 6, 2017·Computer Methods in Biomechanics and Biomedical Engineering·Mir Jalil RazaviXianqiao Wang
Oct 3, 2017·Cerebral Cortex·Fangfei GeTianming Liu
Sep 15, 2016·Physical Review. E·Mir Jalil RazaviXianqiao Wang
Sep 26, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K E GarciaP V Bayly
Sep 2, 2017·Frontiers in Computational Neuroscience·Mir Jalil RazaviTianming Liu

Citations

Jun 14, 1975·Science·V S CavinessV S Caviness
Jan 1, 1988·Anatomy and Embryology·Karl ZillesH J Kretschmann
Jul 8, 1988·Science·P Rakic
Jun 1, 1995·Neuropediatrics·William B Dobyns, C L Truwit
Apr 1, 1994·Journal of Biomechanics·E K RodriguezA D McCulloch
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Nov 1, 2001·Nature Neuroscience·E S Monuki, C A Walsh
May 11, 2002·Journal of Biomechanical Engineering·Michael T Prange, Susan S Margulies
Oct 7, 2003·Annual Review of Neuroscience·Elizabeth A Grove, Tomomi Fukuchi-Shimogori
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paul J McCrackenRichard L Ehman
Mar 11, 2005·Cerebral Cortex·Roberto Toro, Yves Burnod
May 4, 2005·Trends in Cognitive Sciences·Gerhard Roth, Ursula Dicke
Nov 30, 2005·Nature Reviews. Molecular Cell Biology·Magdalena Götz, Wieland B Huttner
Oct 5, 2007·NeuroImage·Scott A KruseRichard L Ehman
May 13, 2008·The Neurologist·Trudy PangVolney Sheen
Jul 25, 2008·Biomechanics and Modeling in Mechanobiology·Gang XuL A Taber
Jul 15, 2009·Brain and Cognition·Tomás Paus
Feb 5, 2010·Journal of the Mechanical Behavior of Biomedical Materials·J A W van DommelenG W M Peters
Feb 24, 2010·NeuroImage·Jeffrey RogersDavid C Glahn
May 18, 2010·NeuroImage·Kaiming LiTianming Liu
Jul 30, 2011·Physical Review Letters·Julien DervauxMartine Ben Amar
Aug 3, 2011·Neuroimaging Clinics of North America·Charles Raybaud, Elysa Widjaja
Feb 7, 2013·Physical Review Letters·T TallinenL Mahadevan
Feb 19, 2013·Trends in Neurosciences·Karl ZillesKatrin Amunts
Apr 2, 2013·Cerebral Cortex·Lisa RonanPaul C Fletcher
Apr 10, 2013·Journal of the Mechanical Behavior of Biomedical Materials·P V BaylyC D Kroenke
Jul 11, 2014·Scientific Reports·Silvia BuddayEllen Kuhl
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tuomas TallinenL Mahadevan
Sep 10, 2014·Journal of the Mechanics and Physics of Solids·Silvia BuddayEllen Kuhl
Sep 18, 2014·Journal of Child Neurology·Birendra RaiLiz Elizabeth Dunbar

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