Abstract
The role of the medial preoptic area (mPOA) beta adrenergic receptors in the regulation of sleep-wakefulness (S-W) was investigated in this study. S-W was assessed on the basis of polygraphic recording of EEG, EMG and EOG in free moving rats. Intracerebral microinjection of beta agonist, isoproterenol, into the mPOA produced arousal. The study was also conducted on another set of rats in which noradrenergic (NE) innervation to the mPOA was destroyed by injecting 6-hydroxydopamine into the ventral noradrenergic bundle, in the brain stem. Local application of isoproterenol, into the mPOA, in these animals, did not produce any significant change in S-W. Thus, the increase in awake period obtained on isoproterenol administration was the result of its action on the presynaptic NE terminals. Possible involvement of other responses in the isoproterenol induced increase in wakefulness, is discussed.
References
Oct 22, 1976·Histochemistry·J C Torre, J W Surgeon
Dec 1, 1976·Experimental Neurology·T Ljungberg, U Ungerstedt
Sep 18, 1992·Brain Research·B N Mallick, M N Alam
Apr 1, 1990·Japanese Journal of Pharmacology·K OhnoY Misu
Apr 1, 1988·Experimental Neurology·S DattaB Singh
Sep 1, 1970·Physiology & Behavior·C Timo-IariaT Leme da Rocha
Nov 26, 1984·Brain Research·V Mohan KumarB Singh
Jul 20, 1981·Brain Research·N BaggaB Singh
Jan 1, 1994·The Japanese Journal of Physiology·J JohnH Mallick
Jan 1, 1995·Physiology & Behavior·V RameshH Mallick
Jan 1, 1993·Brain Research Bulletin·V M KumarS K Manchanda
Jun 1, 1993·Neuroreport·F J García-LadonaF Picatoste
Jan 1, 1996·Behavioural Brain Research·H MallickV M Kumar
Aug 1, 1962·Experimental Neurology·M B STERMAN, C D CLEMENTE
Aug 1, 1962·Experimental Neurology·M B STERMAN, C D CLEMENTE
Feb 11, 1963·Acta Neuropathologica·E TANI, S ISHII
Citations
Sep 27, 2002·Synapse·Craig W Berridge, Thomas A Stalnaker
Apr 2, 2003·Brain Research. Brain Research Reviews·Craig W Berridge, Barry D Waterhouse
Jun 1, 2000·Neuroscience·C W Berridge, K Wifler
Mar 6, 2003·Neuroscience·K K GuliaV M Kumar
Sep 3, 1999·Neuroscience·C W BerridgeK Wifler
Mar 24, 1998·Brain Research Bulletin·J K DhawanP Raghunathan
Nov 6, 2003·Journal of Chemical Neuroanatomy·Velayudhan Mohan Kumar
Mar 21, 2001·Behavioral Neuroscience·C W Berridge, J O'Neill
Sep 24, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Petra MakelaRobert D Rogers
Jan 17, 2016·Brain Research·Rodrigo A EspañaCraig W Berridge
Nov 20, 2012·Sleep Medicine Clinics·Christopher J WatsonRalph Lydic
Feb 3, 2012·Sleep Medicine Reviews·Craig W BerridgeRodrigo A España
Jan 18, 2008·Brain Research Reviews·Craig W Berridge
Mar 15, 2006·Physiology & Behavior·Ramalingam VetrivelanVelayudhan Mohan Kumar
Apr 4, 2007·Neurochemistry International·Velayudhan Mohan KumarHruda Nanda Mallick
Apr 20, 2004·Obesity Research·Nicholas A TritosEleftheria Maratos-Flier
Aug 13, 2014·Journal of Neuroendocrinology·P B MarangonL L K Elias
Aug 26, 2006·Neurochemical Research·Velayudhan Mohan KumarHruda Nanda Mallick
Aug 31, 2021·Life Sciences·Rui ZhangHua-Jun Feng
Oct 24, 2001·The Journal of Organic Chemistry·Stephen M. HusbandsAmy Hauck Newman
May 5, 2009·Neuroscience·S M Miller, J S Lonstein