Role of medial preoptic area beta adrenoceptors in the regulation of sleep-wakefulness

Pharmacology, Biochemistry, and Behavior
S SoodV M Kumar

Abstract

The role of the medial preoptic area (mPOA) beta adrenergic receptors in the regulation of sleep-wakefulness (S-W) was investigated in this study. S-W was assessed on the basis of polygraphic recording of EEG, EMG and EOG in free moving rats. Intracerebral microinjection of beta agonist, isoproterenol, into the mPOA produced arousal. The study was also conducted on another set of rats in which noradrenergic (NE) innervation to the mPOA was destroyed by injecting 6-hydroxydopamine into the ventral noradrenergic bundle, in the brain stem. Local application of isoproterenol, into the mPOA, in these animals, did not produce any significant change in S-W. Thus, the increase in awake period obtained on isoproterenol administration was the result of its action on the presynaptic NE terminals. Possible involvement of other responses in the isoproterenol induced increase in wakefulness, is discussed.

References

Sep 1, 1970·Physiology & Behavior·C Timo-IariaT Leme da Rocha
Jan 1, 1994·The Japanese Journal of Physiology·J JohnH Mallick
Jan 1, 1995·Physiology & Behavior·V RameshH Mallick
Jan 1, 1993·Brain Research Bulletin·V M KumarS K Manchanda
Jun 1, 1993·Neuroreport·F J García-LadonaF Picatoste

❮ Previous
Next ❯

Citations

Apr 2, 2003·Brain Research. Brain Research Reviews·Craig W Berridge, Barry D Waterhouse
Nov 6, 2003·Journal of Chemical Neuroanatomy·Velayudhan Mohan Kumar
Sep 24, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Petra MakelaRobert D Rogers
Jan 17, 2016·Brain Research·Rodrigo A EspañaCraig W Berridge
Nov 20, 2012·Sleep Medicine Clinics·Christopher J WatsonRalph Lydic
Feb 3, 2012·Sleep Medicine Reviews·Craig W BerridgeRodrigo A España
Jan 18, 2008·Brain Research Reviews·Craig W Berridge
Mar 15, 2006·Physiology & Behavior·Ramalingam VetrivelanVelayudhan Mohan Kumar
Apr 20, 2004·Obesity Research·Nicholas A TritosEleftheria Maratos-Flier
Aug 26, 2006·Neurochemical Research·Velayudhan Mohan KumarHruda Nanda Mallick
May 5, 2009·Neuroscience·S M Miller, J S Lonstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.