Role of medical imaging for immune checkpoint blockade therapy: From response assessment to prognosis prediction

Cancer Medicine
Hong WeiBin Song

Abstract

Immune checkpoint blockade (ICB) represents a promising approach in cancer therapy. Owing to the peculiar biologic mechanisms of anticancer activity, checkpoint blockers are accompanied with distinctive response patterns and toxicity profiles. Medical imaging is the cornerstone for response assessment to immunotherapy and plays a critical role in monitoring of immune-related adverse events (irAEs). Imaging-based biomarkers have shown tremendous potential for the prediction of therapeutic efficacies and clinical outcomes in patients treated with checkpoint inhibitors. In this article, the landscape of current response assessment systems for immunotherapy was reviewed with a special focus on the latest advances in the assessment of responses to ICB. Emerging imaging biomarkers were discussed along with the challenges regarding their clinical transformation. In addition, the biological mechanisms and clinical applications of ICB and irAEs were also within the scope of this review.

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Feb 23, 2020·The International Journal of Biological Markers·Rossella CaneseEgidio Iorio
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Dec 17, 2020·CA: a Cancer Journal for Clinicians·Lynne W ElmoreWilliam C Phelps
Aug 18, 2021·Cancer Treatment and Research Communications·Davide MauriAndreas Fotopoulos

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Methods Mentioned

BETA
imaging techniques
xenograft
biopsy

Software Mentioned

iRECIST
irRECIST

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