Role of melatonin in ameliorating lead induced haematotoxicity

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
A I OthmanM A El-Missiry

Abstract

Owing to the risks of heavy metals-induced severe haematopoietic disorders, it is important to investigate these chemicals for their haematotoxicity and the possible ways to ameliorate their toxicity. The effects of melatonin on lead-induced haematotoxicity have, therefore, been examined in rat blood and bone marrow. When adult male rats were injected intramuscularly with lead acetate (10 mg kg(-1)) daily for 7 days, the erthrocytic count, haematocrite value and haemoglobin content were significantly decreased. The counts of platelets, total leucocytes and lymphocytes in the peripheral blood were also significantly lower in lead-treated rats than in control animals. The total granulocyte count was significantly elevated in the peripheral blood of the same lead-treated rats. Significant decreases in polychromatic and pyknotic erythroid series as well as lymphocytes in bone marrow of the lead-intoxicated rats were also demonstrated. Meanwhile, the neutrophiles were increased in the same treated rats. The erythropoietin level was significantly decreased and the lead concentration was increased in the plasma of the lead-treated rats compared with the control rats. Bone marrow examination of the rats treated with lead for 7 days sho...Continue Reading

Citations

Dec 23, 2015·International Journal of Molecular Sciences·Arif Tasleem JanQazi Mohd Rizwanul Haq
Jul 6, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nagaraja HaleagraharaThanikachalam Pasupathi
May 8, 2015·Biological Trace Element Research·Ashraf M Abdel-MoneimIsmail A Sadek
Jun 24, 2006·Ecotoxicology and Environmental Safety·M A El-MissiryA A El-Sayed
Jun 21, 2005·Toxicology·Gamal H El-SokkaryEsam S Kamel
Sep 4, 2014·BioMed Research International·Bechan SharmaNikhat J Siddiqi
Aug 14, 2019·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Madiha Khalid, Mohammad Abdollahi
Sep 8, 2017·British Journal of Pharmacology·Tian LiYang Yang

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