Role of melatonin in the regulation of autophagy and mitophagy: a review

Molecular and Cellular Endocrinology
Ana Coto-MontesRussel J Reiter

Abstract

Oxidative stress plays an essential role in triggering many cellular processes including programmed cell death. Proving a relationship between apoptosis and reactive oxygen species has been the goal of numerous studies. Accumulating data point to an essential role for oxidative stress in the activation of autophagy. The term autophagy encompasses several processes including not only survival or death mechanisms, but also pexophagy, mitophagy, ER-phagy or ribophagy, depending of which organelles are targeted for specific autophagic degradation. However, whether the outcome of autophagy is survival or death and whether the initiating conditions are starvation, pathogens or death receptors, reactive oxygen species are invariably involved. The role of antioxidants in the regulation of these processes, however, has been sparingly investigated. Among the known antioxidants, melatonin has high efficacy and, in both experimental and clinical situations, its protective actions against oxidative stress are well documented. Beneficial effects against mitochondrial dysfunction have also been described for melatonin; thus, this indoleamine seems to be linked to mitophagy. The present review focuses on data and the most recent advances relat...Continue Reading

References

Feb 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·L MalinaI A Magnus
Apr 15, 1975·Annals of the New York Academy of Sciences·J D Spikes
Mar 1, 1985·Archives of Biochemistry and Biophysics·J F TurrensA L Lehninger
Jan 1, 1986·Journal of Pineal Research·R L SackC M Singer
Oct 1, 1980·The Journal of Endocrinology·S F PangG M Brown
Dec 3, 1980·Biochimica Et Biophysica Acta·S Sandberg, I Romslo
Dec 19, 1980·Science·R J ReiterD T Dinh
May 1, 1995·Journal of Pineal Research·C M CagnoliH Manev
Nov 1, 1995·Journal of Pineal Research·R M SainzA Menendez-Pelaez
Sep 1, 1996·Trends in Genetics : TIG·B K Kennedy, L Guarente
Aug 1, 1997·Microscopy Research and Technique·A Coto-MontesE Sánchez-Barceló
Sep 24, 1998·Journal of Pineal Research·D X TanG H El-Sokkary
Dec 5, 1998·Biochimica Et Biophysica Acta·L Y ZangV Vallyathan
Jan 14, 1999·Journal of Pineal Research·L I BruscoD P Cardinali
Feb 4, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·R J Reiter, G J Maestroni
Mar 2, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C XiaM Hosokawa
May 8, 1999·Journal of Pineal Research·P L Marchiafava, B Longoni
Jul 19, 2000·Biological Signals and Receptors·R J ReiterJ R Calvo
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·R K Bruick
Mar 29, 2001·Journal of Pineal Research·D Acuña-CastroviejoR J Reiter
Sep 6, 2001·Cell Death and Differentiation·W Bursch
Mar 22, 2002·The International Journal of Biochemistry & Cell Biology·Cristina Tomás-ZapicoAna Coto-Montes
May 29, 2002·Free Radical Biology & Medicine·Cristina Tomás-ZapicoDelio Tolivia
Jul 19, 2002·Journal of Neurochemistry·E HeadC W Cotman
Sep 20, 2002·Skin Pharmacology and Applied Skin Physiology·Tobias W FischerPeter Elsner
Dec 14, 2002·Developmental Cell·Takahiro ShintaniDaniel J Klionsky
Aug 29, 2003·Cellular and Molecular Life Sciences : CMLS·R M SainzR J Reiter
Nov 19, 2003·Microbes and Infection·Kiley S McGlauchlen, Laura A Vogel
Mar 25, 2004·Journal of Leukocyte Biology·Timothy P PlackettElizabeth J Kovacs
Apr 23, 2004·Trends in Cell Biology·Ana Maria Cuervo
Jun 24, 2004·Seminars in Cell & Developmental Biology·Yoshinori Ohsumi, Noboru Mizushima

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Citations

Sep 28, 2015·The International Journal of Biochemistry & Cell Biology·Xin-Yu ZhangYan-Mei Yang
Feb 1, 2013·Journal of Pineal Research·Seung-Il ChoiEung Kweon Kim
Nov 13, 2014·Journal of Pineal Research·Francisco OrtizGermaine Escames
Sep 19, 2014·Journal of Pineal Research·Jenelle GovenderAnna-Mart Engelbrecht
Oct 19, 2013·Journal of Pineal Research·Beatriz de Luxán-DelgadoAna Coto-Montes
Oct 15, 2013·The Journal of Obstetrics and Gynaecology Research·Hiroshi TamuraNorihiro Sugino
Nov 13, 2015·Archives of Biochemistry and Biophysics·Shenglan LiuJianmin Jiang
Aug 30, 2013·Journal of Pharmacological Sciences·Golmaryam SarlakPiyarat Govitrapong
Apr 9, 2015·Animal : an International Journal of Animal Bioscience·A Rubio-GonzálezA Coto-Montes
May 10, 2015·Journal of Proteomics·Valentina LongoLello Zolla
May 25, 2013·Molecular and Cellular Endocrinology·Naoko TsukamotoHirofumi Makino
Apr 14, 2016·International Journal of Molecular Sciences·Yeong-Min YooHan Sung Kim
Jun 5, 2016·Acta Biochimica Et Biophysica Sinica·Lanfang LiZhisheng Jiang
Apr 20, 2016·Journal of Pineal Research·Beatriz de Luxán-DelgadoAna Coto-Montes
Jul 29, 2016·Journal of Pineal Research·Carlos QuintanaJosé Quintana
Oct 1, 2016·Oxidative Medicine and Cellular Longevity·Janusz BlasiakKai Kaarniranta
Oct 27, 2016·International Journal of Molecular Sciences·Ana Coto-MontesRussel J Reiter
Dec 22, 2016·International Journal of Molecular Sciences·Dun-Xian TanRussel J Reiter
Feb 26, 2016·Biology of Reproduction·Yanzhou YangYanrong Wang
Apr 19, 2017·Animal : an International Journal of Animal Bioscience·Y PotesA Coto-Montes
Jun 29, 2017·Journal of Pineal Research·Almudena CrookeJesús Pintor
Feb 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dun Xian TanRussel J Reiter
Nov 1, 2017·Molecular Neurobiology·Adrian Rubio-GonzálezUNKNOWN Members of Research Team cROS (cellular Response to Oxidative Stress)
Jan 25, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Yan CaoHonglin Liu
Oct 18, 2018·Journal of Pineal Research·Jose A BogaAna Coto-Montes
Jan 1, 2019·Journal of Pineal Research·Yaoyao XiaWenkai Ren
Mar 13, 2019·Journal of Cellular Physiology·Mohammad Mirza-Aghazadeh-AttariBahman Yousefi
Feb 14, 2019·Annals of the New York Academy of Sciences·Mayuri ShuklaRussel J Reiter
Aug 30, 2018·Current Drug Targets·Yanzhou YangWai-Yee Chan

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