Role of melatonin receptor 1A and pituitary homeobox-1 coexpression in protecting tubular epithelial cells in membranous nephropathy

Journal of Pineal Research
Yen-Sung HuangChia-Chao Wu

Abstract

Membranous nephropathy (MN), a type of glomerular nephritis, is one of the most common causes of nephrotic syndrome in adults. Although it is known that melatonin plays a protective role in MN, the role of melatonin receptors in the pathophysiology of MN is unclear. Using an experimental MN model and clinical MN specimens, we studied melatonin receptor expression and found that melatonin receptor 1A (MTNR1A) expression was significantly downregulated in renal tubular epithelial cells. Molecular studies showed that the transcription factor pituitary homeobox-1 (PITX1) promoted MTNR1A expression via direct binding to its promoter. Treatment of a human tubular cell line with albumin to induce injury resulted in the stable reduction in MTNR1A and PITX1 expression. PITX1 levels were significantly downregulated in tubular epithelial cells from mice MN kidneys and MN renal specimens. Knockdown of MTNR1A, PITX1, or cyclic adenosine monophosphate-responsive element-binding protein (CREB) decreased E-cadherin (CDH1) expression, but upregulated Per2 and α-smooth muscle actin (αSMA) expression. Blockade of the MTNR1A receptor with luzindole in MN mice further impaired renal function; this was accompanied by CDH1 downregulation and Per2 and...Continue Reading

References

Jan 1, 1997·Kidney International·G RemuzziA Benigni
Jun 26, 2002·Kidney International·Maria P RastaldiGiuseppe D'Amico
Aug 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard J Glassock
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xinmin ZhangMarc Montminy
Apr 1, 2005·Journal of the American Society of Nephrology : JASN·Daniel Cattran
Jan 7, 2006·The Journal of Investigative Dermatology·Randle M GallucciJames J Tomasek
Feb 3, 2006·Journal of Neuroendocrinology·J D JohnstonD G Hazlerigg
Feb 24, 2007·Current Alzheimer Research·Egemen SavaskanPeter Meyer
Feb 1, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Fernando C FervenzaUlrich Specks
Feb 26, 2008·Breast Cancer Research and Treatment·Xuesong LuAndrea L Richardson
Jun 3, 2008·Journal of Pineal Research·Marina Sánchez-HidalgoCatalina Alarcón de la Lastra Romero
Sep 20, 2008·Nature Reviews. Genetics·Joseph S TakahashiErin L McDearmon
Dec 19, 2009·Journal of the American Society of Nephrology : JASN·Youhua Liu
Apr 10, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard J Glassock
Jan 15, 2011·Journal of Biomedicine & Biotechnology·Chia-Chao WuYuh-Feng Lin
Feb 18, 2011·The New England Journal of Medicine·Hanna Debiec, Pierre Ronco
Mar 26, 2011·Journal of the American Society of Nephrology : JASN·Lisa R Stow, Michelle L Gumz
Jul 15, 2011·Journal of Pineal Research·Annia GalanoRussel J Reiter
Jan 17, 2012·Molecular and Cellular Endocrinology·Radomir M SlominskiAndrzej T Slominski
Mar 1, 2012·Nature Reviews. Nephrology·Pierre Ronco, Hanna Debiec
Mar 28, 2012·Current Opinion in Nephrology and Hypertension·Alton B Farris, Robert B Colvin
Mar 31, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zana Saratlija NovakovicKatarina Vukojevic
Jan 22, 2013·Journal of Pineal Research·Karolina JablonskaPiotr Dziegiel
May 15, 2013·Current Opinion in Nephrology and Hypertension·Olivier Bonny, Dmitri Firsov
Aug 7, 2013·Trends in Cell Biology·Carrie L PartchJoseph S Takahashi
Aug 21, 2013·Genome Research·Wenjun JuMatthias Kretzler
Sep 11, 2013·International Journal of Molecular Sciences·King Hang Chan, Yung Hou Wong
Jun 7, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gianluca TosiniRalf Jockers
Aug 27, 2014·Biochemical and Biophysical Research Communications·Yen-Sung HuangChia-Chao Wu
Aug 28, 2014·Kidney International·Matthias Mack, Motoko Yanagita
Feb 13, 2015·Cell Death & Disease·M D Sanchez-NiñoA Ortiz
Oct 16, 2015·Clinical and Experimental Immunology·R A SinicoA Radice
Oct 31, 2015·Annual Review of Pharmacology and Toxicology·Jiabei LiuMargarita L Dubocovich
Apr 27, 2016·Trends in Endocrinology and Metabolism : TEM·Steven A Brown

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