PMID: 6413802Jul 1, 1983Paper

Role of membrane lipids in the immunological killing of tumor cells: I. Target cell lipids

Lipids
S I Schlager, S H Ohanian

Abstract

The metabolic and physical properties of tumor cells that are associated with their ability to resist or escape from immune attack have been investigated. The susceptibility of P815 murine mastocytoma cells to immune killing can be modulated. Culturing the cells with adriamycin or with hydrocortisone increases or decreases, respectively, the sensitivity of the cells to killing by antibody (Ab) plus complement (C); in addition, culturing the cells with mitomycin C or hydrocortisone increases or decreases, respectively, the sensitivity of the cells to killing by cytotoxic T lymphocytes (CTL). The susceptibility of the cells to Ab-C killing correlates with the ability of the cells to synthesize complex cellular lipids, but not DNA, RNA, protein, or carbohydrate. Further, tumor cells rendered sensitive to Ab-C killing by adriamycin are decreased in total lipid content and in their cholesterol/phospholipid mole ratio; hydrocortisone-treated resistant cells showed the opposite effects. The ability of tumor cells to resist CTL killing did not correlate with their total cellular lipid synthesis, but did correlate with the synthesis and composition of specific cellular phospholipids. In addition, tumor cells increased in sensitivity to ...Continue Reading

References

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Citations

Sep 1, 1991·Biulleten' eksperimental'noĭ biologii i meditsiny·I V KondakovaE V Antipova
Jan 1, 1986·International Journal of Immunopharmacology·K L Erickson
Aug 1, 1985·Prostaglandins, Leukotrienes, and Medicine·M E BéginD F Horrobin
Nov 1, 1987·Prostaglandins, Leukotrienes, and Medicine·F FujiwaraS Imashuku
Jul 12, 2007·Cell Division·Bradley S EllisonRobert J Boackle
Sep 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·K G Lundholm, C Drott
Nov 17, 2019·Medical Hypotheses·Undurti N Das
Apr 30, 2020·Archives of Medical Research·Undurti N Das

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