Role of mesangial Factor V expression in crescent formation in rat experimental mesangioproliferative glomerulonephritis

The Journal of Pathology
Takahiko OnoToru Kita

Abstract

It has been suggested that fibrin deposition participates in the development of crescents in active glomerulonephritis (GN). In human IgA nephropathy, which is a common form of mesangioproliferative GN (MsPGN), crescent formation is occasionally observed in active disease, leading to end-stage renal failure. Factor V is a membrane-bound potent cofactor for the conversion of prothrombin to thrombin by Factor Xa. An in vivo study was conducted to clarify the contribution of local fibrin production to crescent formation in MsPGN through mesangial Factor V expression. Wistar rats were injected intravenously with rabbit anti-rat thymocyte serum. Three days after injection, mesangiolysis with intense mesangial Factor V expression was observed and immunoelectron microscopy revealed fibrin localization in mesangiolytic lesions, which had spread into the glomerular basement membrane adjacent to the destroyed mesangium, accompanied by clots in Bowman's space. Marked glomerular fibrin deposition, together with its deposition in Bowman's space and cellular crescent formation, was noted with mesangial proliferation on day 8. Specific bands for Factor V mRNA were also detected from isolated glomeruli. Fibrin deposition and cellular crescent ...Continue Reading

Citations

Nov 8, 2012·Biological & Pharmaceutical Bulletin·Takahiko OnoTatsuya Morimoto
Dec 18, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Zhangxiu HeLirong Hao
Dec 21, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Keiko NomuraTakahiko Ono
Mar 27, 2007·Clinical and Experimental Nephrology·Ning LiuTakahiko Ono

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