Role of mesenchymal stem cell-derived fibrinolytic factor in tissue regeneration and cancer progression

Cellular and Molecular Life Sciences : CMLS
Beate HeissigKoichi Hattori

Abstract

Tissue regeneration during wound healing or cancer growth and progression depends on the establishment of a cellular microenvironment. Mesenchymal stem cells (MSC) are part of this cellular microenvironment, where they functionally modulate cell homing, angiogenesis, and immune modulation. MSC recruitment involves detachment of these cells from their niche, and finally MSC migration into their preferred niches; the wounded area, the tumor bed, and the BM, just to name a few. During this recruitment phase, focal proteolysis disrupts the extracellular matrix (ECM) architecture, breaks cell-matrix interactions with receptors, and integrins, and causes the release of bioactive fragments from ECM molecules. MSC produce a broad array of proteases, promoting remodeling of the surrounding ECM through proteolytic mechanisms. The fibrinolytic system, with its main player plasmin, plays a crucial role in cell migration, growth factor bioavailability, and the regulation of other protease systems during inflammation, tissue regeneration, and cancer. Key components of the fibrinolytic cascade, including the urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1), are expressed in MSC. This review will in...Continue Reading

References

Apr 1, 1970·Journal of Cellular Physiology·N V LatsinikI L Chertkov
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D J LoskutoffD Lawrence
Jul 1, 1996·Nature Medicine·J RømerK Danø
Jan 28, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·D J Loskutoff, F Samad
Apr 2, 1999·Science·M F PittengerD R Marshak
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D B RifkinJ Sung
Jan 13, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H SolbergL R Lund
Jun 19, 2001·Biochimica Et Biophysica Acta·H R LijnenD Collen
Jan 5, 2002·The Journal of Biological Chemistry·Yuushi OkumuraDavid J Loskutoff
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·M ResnatiF Blasi
Nov 29, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Thomas HerrenEdward F Plow
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Mar 5, 2003·The Journal of Cell Biology·Ralf-Peter CzekayDavid J Loskutoff
Sep 4, 2003·The Journal of Cell Biology·Justin SturgeClare M Isacke
Apr 20, 2004·Cellular and Molecular Life Sciences : CMLS·T Syrovets, Th Simmet
Sep 17, 2004·The EMBO Journal·Linda FredrikssonUlf Eriksson
Sep 17, 2004·Annals of Hematology·J W KimH M Ryu
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amato de PaulisPia Ragno
Nov 24, 2004·Cellular and Molecular Life Sciences : CMLS·H Myöhänen, A Vaheri
Apr 22, 2005·British Journal of Haematology·Gabriela Cesarman-Maus, Katherine A Hajjar
May 6, 2005·The International Journal of Lower Extremity Wounds·Michael SchäfferHorst-Dieter Becker
Oct 21, 2005·Cytotherapy·E M HorwitzUNKNOWN International Society for Cellular Therapy
May 11, 2006·Journal of Cell Science·Lindolfo da Silva MeirellesNance Beyer Nardi

❮ Previous
Next ❯

Citations

Apr 16, 2016·Transfusion·Maryanne C Herzig, Andrew P Cap
Jun 25, 2016·Stem Cells International·Markus Huber-LangRolf E Brenner
Oct 25, 2016·Biochimica Et Biophysica Acta·Gwendal Lazennec, Paula Y Lam
Oct 21, 2016·JBJS Reviews·Thomas J AnJonathan G Schoenecker
Dec 18, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Hanaa S E MousaAisha A El-Khodary
Jul 15, 2016·International Journal of Molecular Sciences·Sandra WinklerBruno Christ
Jul 27, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Liang WangFei Chen
Dec 2, 2019·Stem Cell Reviews and Reports·Pankaj MandpePravin Shende
Jun 1, 2018·World Journal of Stem Cells·Luminita LabuscaKaveh Mashayekhi
Apr 18, 2017·Journal of Dental Research·Y YinF M Chen
Apr 22, 2017·Archives of Dermatological Research·K A RubinaV A Tkachuk
Sep 12, 2018·Cells·Andrea Aparecida de AroEdson Rosa Pimentel
Jul 8, 2020·International Journal of Molecular Sciences·Ehab Kotb ElmahallawyTokuma Yanai
Aug 9, 2020·Seminars in Respiratory and Critical Care Medicine·Declan ByrnesJohn G Laffey
Aug 24, 2017·Biotechnology Journal·Luís P FerreiraJoão F Mano
Mar 7, 2021·International Journal of Molecular Sciences·Beate HeissigKoichi Hattori
Aug 31, 2020·Cellular Signalling·Beate HeissigKoichi Hattori
Apr 4, 2021·International Journal of Molecular Sciences·José Fábio LanaMarco Antonio Percope de Andrade
May 19, 2021·Cytokine·Rafael Gonzalez Dos SantosJosé Fábio Lana
Aug 8, 2021·International Journal of Molecular Sciences·Yousef SalamaBeate Heissig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Related Papers

Bioorganicheskaia khimiia
R B Aĭsina, L I Mukhametova
Surgical Oncology Clinics of North America
S A Rabbani, A P Mazar
Arteriosclerosis, Thrombosis, and Vascular Biology
Arturo Garcia-TouchardRobert S Schwartz
© 2021 Meta ULC. All rights reserved