PMID: 6411485Jan 1, 1983Paper

Role of metabolic rate and DNA-repair in Drosophila aging: implications for the mitochondrial mutation theory of aging

Experimental Gerontology
J MiquelJ Fleming

Abstract

The respective roles of respiration rate and DNA repair in determining the life-span of Drosophila melanogaster have been investigated in three wild strains (Oregon R, Domodedov 32, & Swedish C) and two mutants (w/w & w/mei-41 D5). In agreement with the rate of living theory, there was an inverse relation between oxygen consumption and median life-span in flies having normal DNA repair. In contrast, w/mei-41 D5, showed an abnormally low life-span as compared to the controls. The median life-spans for these flies were: Oregon R, 49; Domodedov 32, 46; Swedish C, 35; w/w, 33; and w/mei-41 D5, 22. Furthermore, this mutant also showed significant deficiency in mating fitness and a depressed metabolic rate. These data suggest that the short life-span of the w/mei-41 D5 is a consequence of a specific syndrome unrelated to normal aging and is not the expression of accelerated senescence. It is proposed that DNA repair mechanisms influence adult life-span by their effect on actively dividing progenitor cells during development rather than by modulating senescence of the resulting differentiated cells of the imago during adulthood.

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Citations

Sep 30, 1987·Mechanisms of Ageing and Development·R S SohalR G Allen
Nov 1, 1987·Mechanisms of Ageing and Development·C B Olson
Nov 1, 1991·Mechanisms of Ageing and Development·K AsanoH Yamagishi
Mar 1, 1991·Archives of Gerontology and Geriatrics·A Ruiz-Torres
Jan 1, 1992·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·R MarcoJ Miquel
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Jan 20, 2011·EMBO Molecular Medicine·Sherif F El-Khamisy
Mar 12, 2004·Molecular Ecology·J William O Ballard, Michael C Whitlock
Sep 2, 2003·Journal of Applied Physiology·Wayne A van VoorhiesJames W Curtsinger
Jul 27, 2000·Annals of the New York Academy of Sciences·S Melov
Apr 27, 2002·Annals of the New York Academy of Sciences·Simon Melov
Jul 1, 1996·Microscopy Research and Technique·P B Nava, R C Mathewson
Aug 1, 1989·Journal of the American Geriatrics Society·R Arking, S P Dudas

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