Role of metalloproteinases in the development and healing of acetic acid-induced gastric ulcer in rats

Scandinavian Journal of Gastroenterology
V M BaragiA Guglietta

Abstract

Matrix metalloproteinases (MMPs) are believed to be active in connective tissue remodeling associated with various physiological processes and in pathological conditions such as cancer and arthritis. However, the role of MMPs in gastrointestinal ulceration has not been clearly established. Therefore, the aim of this study was to examine the role of collagenase and gelatinases A and B in the development and healing of acetic acid-induced gastric ulcer in rats. Gastric ulcer was induced by injecting 20 microliters glacial acetic acid into gastric wall of rat stomachs. To examine whether changes in the ulcer formation and healing phase correlate with MMP activity, Triton X-100/CaCl2 and Tris/CaCl2 (60 degrees C) extracts of stomachs were prepared from controls and animals killed 24 h (formation phase) and 7 days (healing phase) after acetic acid administration. Total collagenase and gelatinase activities were measured using (H3)labeled-acetylated type I collagen or gelatin as substrate, respectively, prepared from rat skin. Twenty-four hours after administration of acetic acid, the mean area of ulcer crater was 51.2 mm2. By day 7, the mean size of ulcer crater was reduced to 35.9 mm2. The mean activity of collagenase in gastric ti...Continue Reading

References

Jan 1, 1990·Digestive Diseases and Sciences·M UchidaO Irino
Apr 1, 1990·Trends in Genetics : TIG·L M Matrisian
Dec 1, 1990·Molecular and Cellular Biology·S M Frisch, J H Morisaki
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·A ItoY Mori
Feb 15, 1984·The Biochemical Journal·D D Dean, J F Woessner
Nov 1, 1994·The British Journal of Dermatology·M S Agren
Jul 1, 1993·The Journal of Investigative Dermatology·A B WysockiF Grinnell

❮ Previous
Next ❯

Citations

May 16, 2012·Biomechanics and Modeling in Mechanobiology·Brendan P FlynnJeffrey W Ruberti
Jul 8, 2011·The British Journal of Nutrition·Sun-Joong KimHyo Ihl Chang
May 20, 1998·Inflammatory Bowel Diseases·T T MacDonald, S L Pender
Sep 7, 2006·Inflammatory Bowel Diseases·Nienke WarnaarTheo A Schuurs
Nov 29, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A TursiG Brandimarte
Sep 29, 1999·Gastroenterology·M D BaughG S Evans
Aug 30, 2001·Microscopy Research and Technique·M ShahinW Domschke
Aug 30, 2006·Scandinavian Journal of Gastroenterology·Francisco J VizosoRichard R R Gava
May 29, 2001·Microscopy Research and Technique·T PohleW Domschke
Oct 23, 2018·World Journal of Gastroenterology : WJG·Larissa Lucena PéricoClélia Akiko Hiruma-Lima
Apr 17, 2019·European Journal of Pharmacology·Ana Flavia S C VianaFlavia A Santos
May 26, 1998·Biochemical and Biophysical Research Communications·M ItoI Sekine

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved