Role of microglial cells in photoreceptor degeneration

Neural Regeneration Research
Johnny Di PierdomenicoMaría Paz Villegas-Pérez

Abstract

Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world. They comprise various diseases, but retinitis pigmentosa is the most frequently observed. Retinitis pigmentosa is commonly limited to the eye, where there is progressive photoreceptor degeneration, rods and secondarily cones. The mechanisms of cone and rod degeneration continue to be investigated, since most of the mutations causing retinitis pigmentosa affect rods and thus, the secondary death of cones is an intriguing question but, ultimately, the cause of blindness. Understanding the mechanisms of rod and cone degeneration could help us to develop therapies to stop or, at least, slow down the degeneration process. Secondary cone degeneration has been attributed to the trophic dependence between rods and cones, but microglial cell activation could also have a role. In this review, based on previous work carried out in our laboratory in early stages of photoreceptor degeneration in two animal models of retinitis pigmentosa, we show that microglial cell activation is observed prior to the the initiation of photoreceptor death. We also show that there is an increase of the retinal microglial cell densities and invasio...Continue Reading

References

May 17, 2002·Experimental Eye Research·Harris Ripps
Jun 29, 2004·Nature Genetics·Thierry LéveillardJosé-Alain Sahel
Mar 4, 2005·Journal of Cellular Physiology·Jikui ShenPeter A Campochiaro
Nov 23, 2006·Lancet·Dyonne T HartongThaddeus P Dryja
Apr 5, 2007·Journal of Leukocyte Biology·Thomas Langmann
Dec 18, 2008·Experimental Eye Research·Bin LinEnrica Strettoi
Mar 23, 2010·Cell·Christopher K GlassFred H Gage
Oct 20, 2010·Experimental Eye Research·Diego García-AyusoMaría P Villegas-Pérez
Feb 15, 2011·Experimental Eye Research·M C Sánchez-MigallónM Agudo-Barriuso
Jan 12, 2013·Investigative Ophthalmology & Visual Science·Caridad Galindo-RomeroMarta Agudo-Barriuso
Aug 3, 2013·Investigative Ophthalmology & Visual Science·Diego García-AyusoMaría P Villegas-Pérez
Dec 12, 2013·The British Journal of Ophthalmology·Diego García-AyusoMaría P Villegas-Pérez
Jan 15, 2014·Survey of Ophthalmology·Anton M Kolomeyer, Marco A Zarbin
Nov 2, 2014·Journal of Neuroinflammation·Agustina NoaillesNicolás Cuenca
Jul 23, 2015·Investigative Ophthalmology & Visual Science·Diego García-AyusoMaría P Villegas-Pérez
Jun 29, 2016·Acta Ophthalmologica·Daniel S NarayanRobert J Casson
Jul 6, 2016·Investigative Ophthalmology & Visual Science·Johnny Di PierdomenicoMaría Paz Villegas-Pérez
Mar 23, 2017·Frontiers in Neuroanatomy·Johnny Di PierdomenicoMaría P Villegas-Pérez
Nov 4, 2017·Progress in Retinal and Eye Research·Marina França DiasYoung Jik Kwon
Nov 11, 2017·Journal of Neuroinflammation·Francisco M Nadal-NicolásMarta Agudo-Barriuso
Mar 23, 2018·Methods in Molecular Biology·Katharina DannhausenThomas Langmann
May 4, 2018·Advances in Experimental Medicine and Biology·José-Alain Sahel, Thierry Léveillard
Jun 1, 2018·Annual Review of Vision Science·Sean M Silverman, Wai T Wong
Sep 8, 2018·Investigative Ophthalmology & Visual Science·Johnny Di PierdomenicoMaría Paz Villegas-Pérez
Dec 29, 2018·Aging·Francisco M Nadal-NicolásMarta Agudo-Barriuso

❮ Previous
Next ❯

Citations

Aug 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lorena Olivares-GonzálezRegina Rodrigo
Sep 25, 2019·International Journal of Molecular Sciences·Diego García-AyusoMaría P Villegas-Pérez
Apr 2, 2020·Investigative Ophthalmology & Visual Science·Johnny Di PierdomenicoDiego García-Ayuso
Jan 1, 2020·Translational Vision Science & Technology·Francisco J Valiente-SorianoManuel Vidal-Sanz
Oct 4, 2020·International Journal of Molecular Sciences·Johnny Di PierdomenicoMaría P Villegas-Pérez
Jun 4, 2021·Bioconjugate Chemistry·Marco BassettoOlivier Zelphati
Jul 3, 2021·Cells·Soyoung ChoiMaria Francesca Cordeiro
Aug 28, 2021·International Journal of Molecular Sciences·María José González-RiquelmeMarta Agudo-Barriuso
Nov 10, 2021·Translational Vision Science & Technology·Hideo KohnoTadashi Nakano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biology of the Cell
Marie-Noëlle DelyferJosé-Alain Sahel
Advances in Experimental Medicine and Biology
Xue CaiMuna I Naash
Advances in Experimental Medicine and Biology
Ammaji RajalaRaju V S Rajala
© 2022 Meta ULC. All rights reserved