Nov 20, 2019

Role of microRNA-21 in hypertrophic cardiac remodeling

BioRxiv : the Preprint Server for Biology
Ken WatanabeMasafumi Watanabe

Abstract

Hypertension is a major public health problem among with aging population worldwide. It causes cardiac remodeling, including hypertrophy and interstitial fibrosis, which leads to development of hypertensive heart disease (HHD). Although microRNA-21 (miR-21) is associated with fibrogenesis in multiple organs, its impact on hypertrophic cardiac remodeling in hypertension is not known. Circulating miR-21 level was higher in patients with HHD than that in the control subjects. It also positively correlated with serum myocardial fibrotic markers. MiR-21 expression levels were significantly upregulated in the mice hearts after angiotensin II (Ang II) infusion or transverse aortic constriction (TAC) compared with control mice. Expression level of programmed cell death 4 (PDCD4), a main target of miR-21, was significantly decreased in Ang II infused mice and TAC mice compared with control mice. Expression levels of transcriptional activator protein 1 (AP-1) and transforming growth factor-β1 (TGF-β1), which were downstream targets of PDCD4, were increased in Ang II infused mice and TAC mice compared with control mice. In vitro, mirVana-miR-21-specific inhibitor attenuated Ang II-induced PDCD4 downregulation and contributed to subsequent...Continue Reading

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Mentioned in this Paper

Biological Markers
Enzyme Inhibitor Drugs
ATP2C1
Fibrogenesis
Protein Kinase C Deactivation
MIRN21 microRNA, mouse
Hypertrophy
Atrial Remodeling
Transforming Growth Factor Beta 1
Interstitial Fibrosis

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