Role of microRNA-7 in digestive system malignancy

World Journal of Gastrointestinal Oncology
Wan-Qun ChenHai-Xia Deng

Abstract

There are several malignancies of the digestive system (including gastric, pancreatic and colorectal cancers, and hepatocellular carcinoma), which are the most common types of cancer and a major cause of death worldwide. MicroRNA (miR)-7 is abundant in the pancreas, playing an important role in pancreatic development and endocrine function. Expression of miR-7 is downregulated in digestive system malignancies compared with normal tissue. Although there are contrasting results for miR-7 expression, almost all research reveals that miR-7 is a tumor suppressor, by targeting various genes in specific pathways. Moreover, miR-7 can target different genes simultaneously in different malignancies of the digestive system. By acting on many cytokines, miR-7 is also involved in many gastrointestinal inflammatory diseases as a significant carcinogenic factor. Consequently, miR-7 might be a biomarker or therapeutic target gene in digestive system malignancies.

Citations

Jun 8, 2018·The International Journal of Biological Markers·Rui JiYongning Zhou
Jun 15, 2017·World Journal of Gastroenterology : WJG·Bao-Min ShiXiu-Yan Wang
Sep 5, 2019·Mini Reviews in Medicinal Chemistry·Miao LiJun Dou
Jul 21, 2020·BioMed Research International·Wanjuan XueJiming Han
May 29, 2021·Database : the Journal of Biological Databases and Curation·Debarati RoychowdhuryK Vijay-Shanker

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