Role of MicroRNAs in NAFLD/NASH

Digestive Diseases and Sciences
Gyongyi Szabo, Timea Csak

Abstract

MicroRNAs (miRNAs) are highly conserved, small, 18-25 nucleotide, non-coding RNAs that regulate gene expression at the post-transcriptional level. Each miRNA can regulate hundreds of target genes, and vice versa each target gene can be regulated by numerous miRNAs, suggesting a very complex network and explaining how miRNAs play pivotal roles in fine-tuning essentially all biological processes in all cell types in the liver. Here, we summarize the current knowledge on the role of miRNAs in the pathogenesis and diagnosis of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) with an outlook to the broader aspects of metabolic syndrome. Furthermore, we discuss the role of miRNAs as potential biomarkers and therapeutic targets in NAFLD/NASH.

References

Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhiping LiAnna Mae Diehl
Sep 17, 2004·Nature·Victor Ambros
Feb 7, 2006·Cell Metabolism·Christine EsauBrett P Monia
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
Mar 28, 2008·Nature·Joacim ElménSakari Kauppinen
May 24, 2008·Molecular Cell·Ulf Andersson ØromAnders H Lund
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Aug 30, 2008·Nature Clinical Practice. Rheumatology·Esmerina TiliCarlo M Croce
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Munekazu YamakuchiCharles J Lowenstein
Nov 26, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Onpan CheungArun J Sanyal
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Dec 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Arumugam VelayudhamGyongyi Szabo
Mar 5, 2009·PloS One·Nora KlötingMatthias Blüher
Mar 18, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca MieleAntonio Grieco
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
Apr 18, 2009·Journal of Lipid Research·Shengjie LiChen-Yu Zhang
May 23, 2009·Cell Death and Differentiation·H Hermeking
Aug 28, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bo WangSamson T Jacob
Oct 13, 2009·Molecular Endocrinology·Jay C StrumK Michelle Waters
Feb 4, 2010·PloS One·Francisco J OrtegaJosé M Fernández-Real
Mar 6, 2010·Science·Matam Vijay-KumarAndrew T Gewirtz
May 15, 2010·Science·S Hani Najafi-ShoushtariAnders M Näär
Jul 14, 2010·Biochemical and Biophysical Research Communications·Rumiko OgawaNaohito Aoki
Aug 12, 2010·Anti-cancer Agents in Medicinal Chemistry·Ioannis Legakis, Kostantinos Syrigos
Sep 8, 2010·World Journal of Gastroenterology : WJG·Mohamed-H Ahmed, Christopher-D Byrne
Sep 18, 2010·Clinical Chemistry·Jessica A WeberKai Wang
Nov 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Herbert Tilg, Alexander R Moschen
Feb 1, 2011·Nature Immunology·Moshe BitonYinon Ben-Neriah
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason D ArroyoMuneesh Tewari
May 26, 2011·Nucleic Acids Research·Andrey TurchinovichBarbara Burwinkel
Jul 19, 2011·The Journal of Nutritional Biochemistry·Menno HoekstraTheo J C Van Berkel
Feb 3, 2012·Nature·Jorge Henao-MejiaRichard A Flavell
Feb 14, 2012·Journal of Hepatology·György BaffyStephen H Caldwell

❮ Previous
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Citations

Apr 22, 2016·European Heart Journal·Peter WilleitManuel Mayr
May 27, 2016·Journal of Human Genetics·Motoyuki OtsukaKazuhiko Koike
May 31, 2016·Metabolism: Clinical and Experimental·Niki KatsikiChristos S Mantzoros
Feb 25, 2017·Molecular Nutrition & Food Research·Robin A WilsonMatthew B Cooke
Apr 14, 2017·Cell Death & Disease·Pedro M RodriguesRui E Castro
Dec 2, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Avishek Kumar SinghShiv Kumar Sarin
Jul 4, 2017·Journal of Gastroenterology and Hepatology·Vincent Wai-Sun WongGeoff Farrell
Apr 23, 2020·Cells·Valeria Annarita Piazzolla, Alessandra Mangia
Jul 21, 2016·Gut·Samira Benhamouche-Trouillet, Catherine Postic
May 30, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·André L SimãoRui E Castro
Sep 30, 2016·Frontiers of Medicine·Zhen HeWeiping Jia
Oct 3, 2018·World Journal of Gastroenterology : WJG·Jorge-Luis TorresMiguel Marcos
Aug 6, 2019·Current Hepatology Reports·Mazen Noureddin, Arun J Sanyal
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·L F TorresR Otton
Aug 31, 2018·Frontiers in Pharmacology·Sanchari RoyChristoph Roderburg
Nov 20, 2019·Clinical Science·Marta B AfonsoCecília M P Rodrigues
Apr 2, 2019·BioMed Research International·Ruixian HuangBaocan Wang
Oct 28, 2020·Journal of Cellular Physiology·Selda Gezginci-OktayogluSehnaz Bolkent
Jan 21, 2021·Expert Opinion on Investigational Drugs·Naim Alkhouri, Samer Gawrieh
Oct 24, 2020·Nature Reviews. Gastroenterology & Hepatology·Sven FrancqueFrank Tacke
Sep 27, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naim AlkhouriEric Lawitz
Jun 5, 2021·Scientific Reports·Rebeca Escutia-GutiérrezJuan Armendáriz-Borunda
Aug 29, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shashi BalaGyongyi Szabo

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