PMID: 6166527May 1, 1981Paper

Role of microtubuli in the lysosomal degradation of endogenous and exogenous protein in isolated rat hepatocytes

Hoppe-Seyler's Zeitschrift für physiologische Chemie
B Grinde, P O Seglen

Abstract

Colchicine and vinblastine, two well known inhibitors of microtubular function, inhibited endogenous protein degradation as well as protein secretion and the degradation of an exogenous, internalized protein (asialo fetuin), in isolated rat hepatocytes. The inhibitors appeared to selectively affect the lysosomal pathway of degradation, since their effects were not additive to that of ammonia, a lysosomotropic degradation inhibitor.

References

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Citations

May 1, 1996·Molecular and Chemical Neuropathology·P S Aisen
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R Miettinen, H Reunanen
Jun 1, 1991·The Journal of Cell Biology·H HøyvikP O Seglen
Aug 1, 1984·The Journal of Cell Biology·M MehrabianL H Rome
Jun 14, 2001·Alzheimer Disease and Associated Disorders·P S AisenM Fusco
Aug 1, 1982·Archives of Biochemistry and Biophysics·P B Gordon, P O Seglen
Sep 11, 1992·Journal of Cellular Physiology·A AplinW A Dunn

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