PMID: 6208972Oct 8, 1984

Role of midbrain raphe in stress-induced renin and prolactin secretion

Brain Research
L D van de KarC L Bethea


Stress-induced changes in renin and prolactin secretion were studied using a conditioned emotional response paradigm. Three minutes after being placed in a chamber, the stressed animals received a brief electric shock (1.0 mA for 10 s through the grid floor), then were returned to their home cage. This procedure was repeated for 3 consecutive days. On the fourth day, the rats were placed in the chamber for 3 min, but instead of receiving shock, they were removed and sacrificed. Control animals were treated in the same manner, except that they never received foot shock. The sham-operated stressed rats evidenced significant elevations in plasma renin activity (270%) and prolactin level (550%). Electrolytic lesions in the dorsal raphe nucleus blocked the stress-induced increase in plasma renin activity but did not affect the stress-induced increase in prolactin secretion. Electrolytic lesions in the median raphe nucleus did not affect prolactin levels in either control or stressed animals. However, median raphe lesions led to a significant increase in plasma renin activity in non-stressed rats and potentiated the stress-induced elevation in plasma renin activity. These results suggest that neurons within the dorsal and median raph...Continue Reading


Oct 7, 1985·Life Sciences·J H UrbanM S Brownfield
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·A D LevyL D van de Kar
Nov 26, 2003·Physiology & Behavior·Roberto DomínguezMarcus L Brandao
Feb 1, 1996·Clinical and Experimental Pharmacology & Physiology·L D van de Kar
Dec 29, 1995·Annals of the New York Academy of Sciences·G AguileraB S Akbasak
Sep 1, 1995·The Journal of Clinical Investigation·G AguileraB Sunar-Akbasak
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·L D van de Kar
Jan 12, 1999·Frontiers in Neuroendocrinology·L D van de Kar, M L Blair
Nov 6, 2008·Psychological Reports·Salvatore P Insana, Janie H Wilson
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Aline Nardoni Gonçalves BragaRobson Augusto Souza dos Santos


Jun 1, 1979·Journal of Human Stress·A P ShapiroS L Syme
Jan 22, 1979·Life Sciences·J P AdvisJ Meites
May 23, 1975·Brain Research·B Srebro, S A Lorens
Aug 1, 1980·Neuroendocrinology·R W Fuller, H D Snoddy
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Mar 1, 1980·Journal of Human Stress·D S Brody

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