Role of miR-140 in embryonic bone development and cancer

Clinical Science
Darrell GreenWilliam D Fraser

Abstract

Bone is increasingly viewed as an endocrine organ with key biological functions. The skeleton produces hormones and cytokines, such as FGF23 and osteocalcin, which regulate an extensive list of homoeostatic functions. Some of these functions include glucose metabolism, male fertility, blood cell production and calcium/phosphate metabolism. Many of the genes regulating these functions are specific to bone cells. Some of these genes can be wrongly expressed by other malfunctioning cells, driving the generation of disease. The miRNAs are a class of non-coding RNA molecules that are powerful regulators of gene expression by suppressing and fine-tuning target mRNAs. Expression of one such miRNA, miR-140, is ubiquitous in chondrocyte cells during embryonic bone development. Activity in cells found in the adult breast, colon and lung tissue can silence genes required for tumour suppression. The realization that the same miRNA can be both normal and detrimental, depending on the cell, tissue and time point, provides a captivating twist to the study of whole-organism functional genomics. With the recent interest in miRNAs in bone biology and RNA-based therapeutics on the horizon, we present a review on the role of miR-140 in the molecul...Continue Reading

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Citations

Apr 6, 2017·Endocrine-related Cancer·Darrell GreenWilliam D Fraser
Feb 20, 2019·Ecological Applications : a Publication of the Ecological Society of America·Daniel MontoyaMichel Loreau
Jan 20, 2018·BMC Genomics·Nicole J WardGrant N Wheeler
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Dec 2, 2020·International Journal of Molecular Sciences·Bárbara Melo-BaezLleretny Rodriguez-Alvarez
Feb 9, 2021·Biochemistry and Biophysics Reports·Shivang ShahNalini Chandar

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