Role of miRNAs in treatment response and toxicity of childhood acute lymphoblastic leukemia

Pharmacogenomics
Maitane UmerezAfrica Garcia-Orad

Abstract

Childhood acute lymphoblastic leukemia survival rates have increased remarkably during last decades due, in part, to intensive treatment protocols. However, therapy resistance and toxicity are still two important barriers to survival. In this context, pharmacoepigenetics arises as a tool to identify new predictive markers, required to guide clinicians on risk stratification and dose individualization. The present study reviews current evidence about miRNA implication on childhood acute lymphoblastic leukemia therapy resistance and toxicity. A total of 12 studies analyzing differential miRNA expression in relation to drug resistance and six studies exploring the association between miRNAs-related SNPs and drug-induced toxicities were identified. We pointed out to miR-125b together with miR-99a and/or miR-100 overexpression as markers of vincristine resistance and rs2114358 in mir-1206 as mucositis marker as the most promising results.

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Citations

Dec 14, 2019·Epigenomics·Angela Gutierrez-CaminoAfrica Garcia-Orad
Nov 16, 2019·Journal of Translational Medicine·Andrea RzepielDániel J Erdélyi
Sep 12, 2018·International Journal of Molecular Sciences·Jaqueline Carvalho de OliveiraMaría Sol Brassesco
Jan 28, 2021·International Journal of Molecular Sciences·Karolina Bukowska-StrakovaMaciej Siedlar
Apr 4, 2021·International Journal of Molecular Sciences·Princess D RodriguezSeth Frietze

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Methods Mentioned

BETA
genotyping
acetylation
antisense oligonucleotides

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