Role of Mitochondria in Cancer Stem Cell Resistance.

Cells
José Manuel García-Heredia, Amancio Carnero

Abstract

Cancer stem cells (CSC) are associated with the mechanisms of chemoresistance to different cytotoxic drugs or radiotherapy, as well as with tumor relapse and a poor prognosis. Various studies have shown that mitochondria play a central role in these processes because of the ability of this organelle to modify cell metabolism, allowing survival and avoiding apoptosis clearance of cancer cells. Thus, the whole mitochondrial cycle, from its biogenesis to its death, either by mitophagy or by apoptosis, can be targeted by different drugs to reduce mitochondrial fitness, allowing for a restored or increased sensitivity to chemotherapeutic drugs. Once mitochondrial misbalance is induced by a specific drug in any of the processes of mitochondrial metabolism, two elements are commonly boosted: an increment in reactive nitrogen/oxygen species and, subsequently, activation of the intrinsic apoptotic pathway.

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Citations

Feb 14, 2021·Experimental Hematology & Oncology·Bing DongKongming Wu
Jan 23, 2021·Cancers·Vanessa CastelliMichele d'Angelo
May 6, 2021·International Journal of Molecular Sciences·Ilaria GenoveseCarlotta Giorgi
May 22, 2021·Cell Death & Disease·Manuel Pedro Jimenez-GarcíaAmancio Carnero
Jun 5, 2021·Life Sciences·Bruna Stefane Alves de OliveiraHafiz M N Iqbal
Nov 14, 2020·Cells·Mario CioceVito Michele Fazio
Jul 11, 2021·Cellular Oncology (Dordrecht)·Michelle van der MerweAnna-Mart Engelbrecht
Aug 8, 2021·Cancers·Mehmet GunduzMuneki Hotomi
Aug 13, 2021·Stem Cell Research & Therapy·Qingyin LinYanzhou Yang
Jul 9, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tingting LiuAlexey V Danilov

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Methods Mentioned

BETA
xenograft
xenografts

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