Role of mitochondria in the differential action of sodium deoxycholate and ursodeoxycholic acid on rat duodenum.

Canadian Journal of Physiology and Pharmacology
Adriana PérezNori G Tolosa de Talamoni

Abstract

Sodium deoxycholate (NaDOC) inhibits the intestinal Ca2+ absorption and ursodeoxycholic acid (UDCA) stimulates it. The aim of this study was to determine whether NaDOC and UDCA produce differential effects on the redox state of duodenal mitochondria altering the Krebs cycle and the electron transport chain (ETC) functioning, which could lead to perturbations in the mitochondrial dynamics and biogenesis. Rat intestinal mitochondria were isolated from untreated and treated animals with either NaDOC, UDCA, or both. Krebs cycle enzymes, ETC components, ATP synthase, and mitochondrial dynamics and biogenesis markers were determined. NaDOC decreased isocitrate dehydrogenase (ICDH) and malate dehydrogenase activities affecting the ETC and ATP synthesis. NaDOC also induced oxidative stress and increased the superoxide dismutase activity and impaired the mitochondrial biogenesis and functionality. UDCA increased the activities of ICDH and complex II of ETC. The combination of both bile acids conserved the functional activities of Krebs cycle enzymes, ETC components, oxidative phosphorylation, and mitochondrial biogenesis. In conclusion, the inhibitory effect of NaDOC on intestinal Ca2+ absorption is mediated by mitochondrial dysfunction...Continue Reading

References

Mar 1, 1992·The Journal of Nutrition·R H WassermanR Kumar
Jan 1, 1990·Methods in Enzymology·R L LevineE R Stadtman
Nov 29, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·J C FischerA J Janssen
Jul 12, 1973·Biochimica Et Biophysica Acta·C O Beauchamp, I Fridovich
May 24, 1995·Biochimica Et Biophysica Acta·L Ernster, G Dallner
Feb 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S KrähenbühlJ Reichen
Jul 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·D ChretienA Munnich
Oct 11, 1993·FEBS Letters·E EstornellG Lenaz
Oct 1, 1996·Comparative Biochemistry and Physiology. Part A, Physiology·N Tolosa de TalamoniA Alisio
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 26, 2002·European Journal of Human Genetics : EJHG·Pierre RustinAgnès Rötig
Oct 7, 2003·Annual Review of Biochemistry·Gary Cecchini
Oct 29, 2004·Molecular and Cellular Biology·Tomotake KankiDongchon Kang
May 16, 2007·The Biochemical Journal·Lena SerranderKarl-Heinz Krause
Dec 7, 2007·Biochimica Et Biophysica Acta·Ana M MarchionattiNori G Tolosa de Talamoni
Apr 11, 2009·World Journal of Gastroenterology : WJG·Maria-J Perez, Oscar Briz
Feb 13, 2010·The Journal of Nutritional Biochemistry·Adriana PérezNori G Tolosa de Talamoni
Apr 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ilenia D'ErricoAntonio Moschetta
Mar 13, 2012·International Journal of Molecular Sciences·Rossana DomenisIrene Mavelli
May 9, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·María A RivoiraNori G Tolosa de Talamoni
Sep 1, 2012·Annual Review of Genetics·David C Chan
May 21, 2013·Biochimica Et Biophysica Acta·Sabine SchulzHans Zischka
Jul 16, 2013·Journal of the National Cancer Institute·Cigdem Himmetoglu UssakliRosa Ana Risques
Oct 8, 2013·Archives of Biochemistry and Biophysics·Valeria RodríguezNori Tolosa de Talamoni
Oct 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Elena BellafanteAntonio Moschetta
Dec 27, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bryan L Copple, Tiangang Li
Dec 29, 2015·Archives of Biochemistry and Biophysics·Valeria A RodríguezNori G Tolosa de Talamoni
Jul 28, 2016·The FEBS Journal·Christina PloumiNektarios Tavernarakis
Feb 12, 2017·Trends in Biochemical Sciences·Ayenachew Bezawork-GeletaJiri Neuzil
Apr 5, 2017·Annual Review of Biochemistry·Lenny Dang, Shin-San Michael Su
Apr 18, 2017·PLoS Neglected Tropical Diseases·Brian PanicucciAlena Zíková
May 20, 2017·World Journal of Gastroenterology : WJG·Gabriela Diaz de BarbozaNori Tolosa de Talamoni
Oct 29, 2017·Annals of Hepatology·Agostino Di CiaulaPiero Portincasa
Nov 19, 2017·Current Medicinal Chemistry·Ana MarchionattiNori Tolosa de Talamoni
Nov 23, 2017·Frontiers in Endocrinology·Patries M HerstMichael V Berridge
Mar 10, 2018·Current Medicinal Chemistry·Marine Blanchet, Jean Michel Brunel
Mar 27, 2018·Molecular Nutrition & Food Research·Dongtao WangShunmin Li
Jul 22, 2018·Essays in Biochemistry·Lisa TilokaniJulien Prudent
Oct 3, 2018·Aging and Disease·Fan LiuQin Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives of Biochemistry and Biophysics
Valeria A RodríguezNori G Tolosa de Talamoni
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
María A RivoiraNori G Tolosa de Talamoni
Current Medicinal Chemistry
Ana M MarchionattiNori G Tolosa de Talamoni
© 2021 Meta ULC. All rights reserved