Role of MMP-2 (-1306 C/T) Polymorphism in Age-Related Macular Degeneration

Ophthalmic Genetics
Rasa LiutkevicieneAbdonas Tamosiunas

Abstract

To determine if the frequency of the MMP-2 (-1306 C/T) genotype has an influence on the development of early age-related macular degeneration (AMD). The study enrolled 387 patients with early AMD and a random sample of 682 healthy persons (control group). The genotyping of MMP-2 (-1306 C/T) was carried out using the real-time polymerase chain reaction method. The analysis of the MMP-2 (-1306 C/T) gene polymorphism did not reveal any differences in the genotype distribution between the patients with AMD and the control subjects. When the study population was divided into age groups, the C/C genotype was more prevalent in the AMD patients aged <65 years than those aged ≥65 years (65.19% versus 53.88%, p = 0.0294), and the C/T genotype was more frequent in the AMD patients aged ≥65 years when compared with the AMD patients aged <65 years (40.78% versus 26.52%, p = 0.0037). Moreover, in the female group younger than 65 years, the frequency of the C/C genotype was greater in the AMD group than the control group (75% versus 58.91%, p = 0.0232). This study showed a significantly greater prevalence of the C/C and C/T genotypes in the patients with AMD younger than 65 years and those aged ≥65 years, respectively. Moreover, the AMD women...Continue Reading

References

May 16, 2002·Current Opinion in Ophthalmology·Leslie Hyman, Rebecca Neborsky
Dec 31, 2002·Investigative Ophthalmology & Visual Science·Maria E Marin-CastañoScott W Cousins
Dec 31, 2002·Investigative Ophthalmology & Visual Science·Lennart BerglinAnders Kvanta
Feb 26, 2003·Investigative Ophthalmology & Visual Science·Scott W CousinsSharon Elliot
Feb 28, 2004·Cardiology·Rabih A ChaerMalek G Massad
Mar 12, 2004·American Journal of Ophthalmology·Ronald KleinMylan R Vannewkirk
Apr 14, 2004·Archives of Ophthalmology·David S FriedmanUNKNOWN Eye Diseases Prevalence Research Group
Apr 14, 2004·Archives of Ophthalmology·Marco A Zarbin
May 4, 2007·The British Journal of Ophthalmology·Olcay TatarSalvatore Grisanti
Mar 25, 2008·American Journal of Epidemiology·Robin L SeitzmanUNKNOWN Study of Osteoporotic Fractures Research Group
Apr 19, 2011·Investigative Ophthalmology & Visual Science·Ali A HussainJohn Marshall
Oct 2, 2013·Ophthalmic Genetics·Rasa LiutkevicieneAbdonas Tamosiunas

❮ Previous
Next ❯

Citations

Apr 30, 2020·European Journal of Ophthalmology·Aishwarya MuraliSowmya Parameswaran
Mar 8, 2019·PloS One·Ricardo Usategui-MartínJosé Carlos Pastor
Aug 23, 2020·International Journal of Molecular Sciences·Luis García-OnrubiaSalvador Pastor-Idoate

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.