Role of mobile passenger lymphocytes in the rejection of renal and cardiac allografts in the rat. A passenger lymphocyte-mediated graft-versus-host reaction amplifies the host response

Transplantation
R van SchilfgaardeP J van Breda Vriesman

Abstract

It is demonstrated that passenger lymphocytes migrate out of rat renal allografts into host spleens in a radioresistant fashion. These mobile passenger lymphocytes within BN kidney and heart transplants are immunocompetent, since they elicit a graft-versus-host (GVH) reaction in the spleens of (LEW x BN)F2 hybrid hosts. The greater GVH reaction in (LEW x BN)F1 recipients of BN kidneys reflects the greater number of mobile passenger lymphocytes in the kidney when compared to the heart. The mobile passenger lymphocytes within BN renal allografts also cause a proliferative response in the spleens of LEW hosts as well as an accelerated rejection of BN renal allografts when compared to BN cardiac allografts, for the differences between BN kidney and heart, both in terms of splenomegaly elicited in LEW as well as tempo of rejection, are abolished by total body X-irradiation of the donor with 900 rad. Results indicate that a mobile passenger lymphocyte mediated GVH reaction in the central lymphoid organs of the host augments the host response to allogeneic kidneys and contributes materially to first-set renal allograft rejection; this GVH reaction on the other hand is not conspicuously present in LEW recipients of BN cardiac allograft...Continue Reading

Citations

Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·Y ShimizuN Kamada
May 15, 1997·Transplantation·J H FechnerS J Knechtle
Oct 29, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·A M DiujvestijnP J van Breda Vriesman
Feb 1, 1982·Kidney International·H L BromJ L Terpstra
Jul 30, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Simone HoegerBenito A Yard
Jan 18, 2014·Clinical Transplantation·Jei wen ChangG W Burke
Jun 29, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mikko A I KeränenKarl B Lemström
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Related Concepts

Metazoa
Cell Division Phases
Cell Motility
Chromium Radioisotopes
Graft Rejection
Graft Vs Host Reaction
Kidney
Lymphoid Cells
Myocardium
Rats, Inbred BN

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