PMID: 11901936Mar 21, 2002Paper

Role of molecular biology in the follow-up of patients who have Barrett's esophagus

Chest Surgery Clinics of North America
A G Casson

Abstract

At present, the follow-up of patients who have Barrett's esophagus (BE) should occur within the setting of an endoscopic biopsy surveillance program and with the frequency of surveillance as proposed by the American College of Gastroenterology. In the future, patients who have BE will be further stratified according to their risk for progression to invasive carcinoma. This stratification will permit the development of more rational surveillance programs. Models that incorporate epidemiologic risk factors, reflux symptoms, and endoscopic and histologic findings will likely include panels of biomarkers for further stratification of patients as low, intermediate, or high risk. Therefore, the challenge over the next decade will be to define the role of molecular markers in endoscopic surveillance strategies and to identify additional clinically relevant molecular markers for prognosis as intermediate markers for chemoprevention and as molecular targets for novel gene therapies.

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Citations

Oct 2, 2009·Future Oncology·Lloyd Balbuena, Alan G Casson
Nov 26, 2009·Expert Review of Gastroenterology & Hepatology·Luca QuaroniAlan G Casson
Sep 21, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P J VeugelersA G Casson
Aug 18, 2005·Thoracic Surgery Clinics·Simon Turcotte, André Duranceau
Jan 24, 2006·Seminars in Thoracic and Cardiovascular Surgery·Alan G CassonDuane L Guernsey
Jul 29, 2004·Cancer Letters·Susan C EvansAlan G Casson
Apr 23, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Manisha BajpaiKiron M Das
Jun 23, 2005·Cancer·Alan G CassonDuane L Guernsey

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