PMID: 1202017Dec 1, 1975Paper

Role of molecular charge in glomerular permeability. Tracer studies with cationized ferritins

The Journal of Cell Biology
H G RennkeM A Venkatachalam

Abstract

Mouse kidneys were perfused with Krebs-Ringer bicarbonate buffer (KRB) containing native, anionic horse spleen ferritin or various cationized derivatives, and the glomerular localization of the probe molecules determined by electron microscopy. Ferritins cationic with respect to the medium (KRB, pH 7.45) accumulated in the subendothelial layers of the glomerular basement membrane (GBM) in amounts far exceeding those observed with anionic ferritins, the degree being greater for the more cationized derivatives. Strongly cationized ferritins, in addition permeated the full thickness of the GBM in considerable amounts, but appeared to be retarded from entry into the urinary spaces at the level of the filtration slits. Very strongly cationized derivatives adhered to glomerular endothelium and GBM and formed aggregates in the outer layers of the latter. The results suggest that intrinsic negative charges are present in the GBM and endothelium, and that the barrier function of the glomerular capillary wall may be ascribed in part to its electrophysical properties.

References

Apr 1, 1975·The Journal of Cell Biology·M J Karnovsky, G B Ryan
Sep 15, 1970·Biochemistry·N G Westberg, A F Michael
Mar 1, 1972·Journal of Ultrastructure Research·D DanonE Skutelsky
Mar 1, 1972·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S K Ainsworth, M J Karnovsky
Sep 25, 1974·Journal of Chromatography·P G Righetti, J W Drysdale
Jun 1, 1970·Experimental and Molecular Pathology·S C Mohos, L Skoza
Feb 1, 1974·The Journal of Cell Biology·R Rodewald, M J Karnovsky
Oct 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·E B Blau, A F Michael
Dec 1, 1970·The Journal of Experimental Medicine·M A VenkatachalamR S Cotran
Mar 1, 1969·The Journal of Cell Biology·J GroniowskiM Walski
Jun 27, 1969·Science·S C Mohos, L Skoza
Dec 1, 1965·Journal of Molecular Biology·G H Haggis
Jul 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·R P Misra, L B Berman
Dec 1, 1966·The Journal of Experimental Medicine·R C Graham, M J Karnovsky
Apr 1, 1954·Biochimica Et Biophysica Acta·J L FARRANT

❮ Previous
Next ❯

Citations

Jul 1, 1995·The Histochemical Journal·P LjungbergH Jalanko
Jan 1, 1983·Archives of Oto-rhino-laryngology·H YamaneY Minowa
Jan 1, 1988·Archives of Oto-rhino-laryngology·M TakumidaH Rask-Andersen
Oct 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E H Garin
Feb 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·K WashizawaH Shigematsu
Sep 16, 1985·Klinische Wochenschrift·H G Rennke
Jan 1, 1983·The Journal of Membrane Biology·W M DeenB M Brenner
Sep 29, 2005·Clinical and Experimental Nephrology·Masaomi Nangaku, William G Couser
Aug 1, 1988·Developmental Biology·B LelongtY S Kanwar
Aug 1, 1988·Cell Differentiation·H HolthöferB A Schulte
Jun 1, 1994·Progress in Neurobiology·K C Wadhwani, S I Rapoport
May 1, 1990·Brain Research Bulletin·L S Perlmutter, H C Chui
Dec 31, 1987·Hearing Research·J J Prieto, J A Merchan
May 1, 1990·Hearing Research·J J PrietoJ A Merchan
Sep 1, 1985·Journal of Ultrastructure Research·J T NielsenE I Christensen
Nov 28, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D W Lin, D R Trune
Jan 20, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Kevin J McCarthy, Deborah J Wassenhove-McCarthy
Apr 16, 2009·Molecular Pharmaceutics·Emily Gullotti, Yoon Yeo
Jun 19, 2013·Nature Reviews. Nephrology·Jung Hee Suh, Jeffrey H Miner
Nov 26, 1999·Kidney International·F RüdigerH Pavenstädt
Apr 13, 1978·The New England Journal of Medicine·B M BrennerH D Humes
Oct 27, 1983·The New England Journal of Medicine·R S Cotran, H G Rennke
Mar 31, 2006·The New England Journal of Medicine·Karl TryggvasonJorma Wartiovaara
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J P Caulfield, M G Farquhar
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·Y S KanwarM L Jakubowski
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·Y S KanwarJ T Gibbons
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·Y S KanwarM L Jakubowski
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y S KanwarM L Jakubowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.