PMID: 9538628Apr 16, 1998Paper

Role of mononuclear cells of IgA nephropathy on ICAM-1 expression in mesangial cells

The Korean Journal of Internal Medicine
T W LeeM J Kim

Abstract

To investigate the possible role of mononuclear cells and their products in the pathogenesis of IgA nephropathy, in vitro expression of ICAM-1 on cultured mouse mesangial cell (MC) was examined after stimulation with mononuclear cell culture supernatant from patients with IgA nephropathy. Peripheral blood mononuclear cells (PBMC) were isolated and cultured from 18 patients with primary IgA nephropathy, 8 normal controls and 5 patients with non-IgA nephropathy (FSGS 1, MGN 3, MPGN 1). ICAM-1 expression on cultured mouse MC by TNF-alpha, IL-1 beta and culture supernants of PBMC were analyzed using a cell ELISA method. The concentration of IL-1 beta and TNF-alpha in culture supernatants was measured by using a commercially available radioimmunoassay kit. Addition of human recombinant TNF-alpha induced an increased ICAM-1 expression in a dose-dependent manner. The expression of ICAM-1 was further increased after co-stimulation with TNF-alpha and IL-1 beta. Addition of PBMC culture supernatants into mouse MC induced significantly higher expression of ICAM-1 by supernatants from the patients with IgA nephropathy compared with that from normal controls. The concentration of TNF-alpha and IL-1 beta in supernatants from the patients wit...Continue Reading

References

Aug 2, 1990·Nature·T A Springer
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Citations

Feb 15, 2005·Journal of Ethnopharmacology·R YatsudaH Koo
Jul 25, 2007·Biochemical and Biophysical Research Communications·Ran Ju KimPyeung-Hyeun Kim

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