Role of morphogenetic proteins in skeletal tissue engineering and regeneration

Nature Biotechnology
A H Reddi

Abstract

Morphogenesis is the developmental cascade of pattern formation and body plan establishment, culminating in the adult form. It has formed the basis for the emerging discipline of tissue engineering, which uses principles of molecular developmental biology and morphogenesis gleaned through studies on inductive signals, responding stem cells, and the extracellular matrix to design and construct spare parts that restore function to the human body. Among the many organs in the body, bone has considerable powers for regeneration and is a prototype model for tissue engineering. Implantation of demineralized bone matrix into subcutaneous sites results in local bone induction. This model mimics sequential limb morphogenesis and has permitted the isolation of bone morphogens, such as bone morphogenetic proteins (BMPs), from demineralized adult bone matrix. BMPs initiate, promote, and maintain chondrogenesis and osteogenesis, but are also involved in the morphogenesis of organs other than bone. The symbiosis of the mechanisms underlying bone induction and differentiation is critical for tissue engineering and is governed by both biomechanics (physical forces) and context (microenvironment/extracellular matrix), which can be duplicated by...Continue Reading

References

Jun 1, 1976·The Journal of Cell Biology·A H Reddi, W A Anderson
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N S CunninghamA H Reddi
Sep 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A I Caplan
Oct 9, 1991·JAMA : the Journal of the American Medical Association·R K KhouriH Reddi
Oct 23, 1987·Science·E Ruoslahti, M D Pierschbacher
Apr 1, 1988·Calcified Tissue International·S Wientroub, A H Reddi
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A H Reddi, C Huggins
Nov 12, 1965·Science·M R Urist
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T K Sampath, A H Reddi
Mar 30, 1984·Biochemical and Biophysical Research Communications·T K Sampath, A H Reddi
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T K Sampath, A H Reddi
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R E Weiss, A H Reddi
Feb 1, 1981·Collagen and Related Research·A H Reddi
Oct 1, 1994·Current Opinion in Genetics & Development·A H Reddi
Oct 28, 1994·Science·D Duboule
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
May 14, 1993·Science·R Langer, J P Vacanti
May 14, 1993·Science·R C Mulligan
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D L GriffithW D Carlson
Jun 1, 1996·Clinical Orthopaedics and Related Research·M BostromT Schildhauer
May 1, 1996·The Journal of Bone and Joint Surgery. American Volume·E B Hunziker, L C Rosenberg
May 1, 1996·Trends in Biotechnology·P J Morris
Dec 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Bank
Jul 25, 1997·Cell·J L Johnson, E A Craig
Aug 1, 1997·Nature Medicine·A H Reddi
Oct 10, 1997·Cell·R L Johnson, C J Tabin

❮ Previous
Next ❯

Citations

Nov 16, 2004·Journal of Biomedical Materials Research. Part a·Atsuhiro SaitoMasao Tanihara
Jan 25, 2002·Journal of Cellular Physiology·V M ParalkarD D Thompson
Apr 25, 2001·Journal of Cellular Physiology·K MiyazonoH Inoue
Jun 8, 2001·Biochemical and Biophysical Research Communications·I SekiyaD J Prockop
Nov 6, 2010·Der Orthopäde·C WedemeyerT Bredendiek
Jun 19, 2013·International Orthopaedics·Araceli Cuellar, A Hari Reddi
Mar 3, 2012·Cell and Tissue Research·Hemin NieJeremy J Mao
Nov 20, 2008·Journal of Bone and Mineral Metabolism·Hiroyuki TominagaTakeshi Imamura
Feb 16, 2005·Annals of Biomedical Engineering·Vassilios I SikavitsasAntonios G Mikos
Jul 31, 2013·Biomedical Microdevices·Yael Lupu-HaberMarcelle Machluf
Dec 1, 2006·Clinical & Experimental Metastasis·Jennifer HalpernGinger E Holt
May 5, 2007·Journal of Biomedical Science·Shuang YangTianhui Zhu
Dec 8, 2010·In Vitro Cellular & Developmental Biology. Animal·Weerachai Singhatanadgit, Irwin Olsen
May 10, 2005·Cytokine & Growth Factor Reviews·Misako Nakashima
Jun 14, 2005·Cytokine & Growth Factor Reviews·A H Reddi
Jan 26, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Courtney A DunnWilliam V Giannobile
Feb 5, 2003·Biochemical and Biophysical Research Communications·Ayako NishiharaA Hari Reddi
Nov 19, 2003·Clinics in Plastic Surgery·Marc H Hedrick, Eric J Daniels
Nov 19, 2003·Clinics in Plastic Surgery·Jeremy S BlumAntonios G Mikos
Oct 31, 2000·Biomaterials·K J BurgJ F Kellam
Jan 13, 2000·Trends in Biotechnology·C A Heath
Sep 1, 2000·Advanced Drug Delivery Reviews·C A Kirker-Head
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Bo HanMarcel E Nimni
Jun 8, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·G Karsenty
Oct 18, 2002·Clinical Otolaryngology and Allied Sciences·A VatsB C Knight

❮ Previous
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