Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography

Journal of Neurophysiology
V SanthakumarI Soltesz

Abstract

Mossy cell loss and mossy fiber sprouting are two characteristic consequences of repeated seizures and head trauma. However, their precise contributions to the hyperexcitable state are not well understood. Because it is difficult, and frequently impossible, to independently examine using experimental techniques whether it is the loss of mossy cells or the sprouting of mossy fibers that leads to dentate hyperexcitability, we built a biophysically realistic and anatomically representative computational model of the dentate gyrus to examine this question. The 527-cell model, containing granule, mossy, basket, and hilar cells with axonal projections to the perforant-path termination zone, showed that even weak mossy fiber sprouting (10-15% of the strong sprouting observed in the pilocarpine model of epilepsy) resulted in the spread of seizure-like activity to the adjacent model hippocampal laminae after focal stimulation of the perforant path. The simulations also indicated that the spatially restricted, lamellar distribution of the sprouted mossy fiber contacts reported in in vivo studies was an important factor in sustaining seizure-like activity in the network. In contrast to the robust hyperexcitability-inducing effects of moss...Continue Reading

References

Dec 15, 1978·The Journal of Comparative Neurology·D G Amaral
Oct 1, 1992·Physiological Reviews·W RallI Segev
Oct 1, 1991·Epilepsy Research·U HeinemannC L Zhang
Sep 1, 1989·Annals of Neurology·T SutulaL Ramirez
Apr 1, 1986·The Journal of Physiology·R Miles, R K Wong
Jul 1, 1987·The Journal of Physiology·R Miles, R K Wong
Aug 1, 1974·Journal of Neurosurgery·B JennettR Braakman
Nov 1, 1984·The Journal of Physiology·G L CollingridgeB Robertson
Feb 1, 1984·Journal of Neurophysiology·R A Fricke, D A Prince
Aug 15, 1995·The Journal of Physiology·T B Kneisler, R Dingledine
Mar 1, 1995·Journal of Neurophysiology·M MiglioreD Johnston
Oct 1, 1993·Journal of Neurophysiology·P S BuckmasterP A Schwartzkroin
Sep 1, 1993·Journal of Neuropathology and Experimental Neurology·D D Armstrong
Jan 1, 1995·Hippocampus·P E Patton, B McNaughton
Mar 4, 1996·The Journal of Comparative Neurology·P S BuckmasterP A Schwartzkroin
Jan 1, 1996·Annual Review of Neuroscience·D JohnstonB R Cristie
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Mar 1, 1997·The European Journal of Neuroscience·A SikG Buzsáki
Aug 15, 1997·Neural Computation·M L Hines, N T Carnevale
Mar 21, 1998·Neuroreport·S Ishizuka, T Kosaka
May 15, 1998·Journal of Computational Neuroscience·J A WhiteN Kopell
Jul 8, 1998·Artificial Intelligence in Medicine·W W LyttonT P Sutula
Feb 26, 1999·Journal of Neurophysiology·P S Buckmaster, F E Dudek

❮ Previous
Next ❯

Citations

Jul 10, 2007·Biological cybernetics·William S AndersonPiotr J Franaszczuk
May 30, 2006·Journal of Computational Neuroscience·M MiglioreM L Hines
Jan 25, 2008·Journal of Computational Neuroscience·Michael L HinesFelix Schürmann
Apr 2, 2008·Journal of Computational Neuroscience·Michael L HinesFelix Schürmann
Sep 6, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ashok K Shetty
Jul 3, 2008·Nature Reviews. Neuroscience·William W Lytton
Apr 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Robert J Morgan, Ivan Soltesz
Apr 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Astrid A Prinz
Jun 10, 2010·Cerebral Cortex·Peter JedlickaStephan W Schwarzacher
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul S Buckmaster, Felicia H Lew
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew BogaardVictoria Booth
Nov 20, 2004·The Journal of Physiology·Csaba FöldyIvan Soltesz
Feb 23, 2013·Computational Intelligence and Neuroscience·Keite Lira de Almeida FrançaAntônio Márcio Rodrigues
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sarah Feldt MuldoonRosa Cossart
Nov 14, 2012·Epilepsy & Behavior : E&B·Julián TejadaNorberto Garcia-Cairasco
Feb 28, 2015·Neurobiology of Learning and Memory·Vassilis Cutsuridis, Panayiota Poirazi
Nov 22, 2008·Journal of Neuroscience Methods·Lauren C FreyKevin Staley
Feb 28, 2006·Epilepsy & Behavior : E&B·Jose E Cavazos, Devin J Cross
Feb 9, 2011·Current Biology : CB·William S Anderson, Gabriel Kreiman
Nov 22, 2011·Experimental Neurology·Suchitra JoshiJaideep Kapur
Sep 23, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Katsuhiro KobayashiJean Gotman
Jan 27, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carl E Stafstrom
Jan 15, 2017·Journal of Neuroinflammation·Kyria M WebsterBridgette D Semple
Feb 6, 2017·Journal of Neuroscience Research·Zoé Christenson WickEsther Krook-Magnuson
Dec 2, 2017·Journal of Neuroscience Research·Eric J NeubergerVijayalakshmi Santhakumar
Jan 22, 2009·Hippocampus·Raphael WinkelsStephan W Schwarzacher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.