Role of mTOR in glioblastoma

Gene
Zekeriya DuzgunCigir Biray Avci

Abstract

Mammalian target of rapamycin (mTOR), which is a member of the serine/threonine protein kinase family, is a protein complex that has a central role of cell growth and proliferation. mTOR emerges as a critical cell growth checkpoint on phosphoinositide 3-kinase (PI3K) signaling pathway. In this case mTOR has become an important therapeutic target for glioblastoma (GBM) that is one of the most deadly types of cancer. Various combination treatments including inhibition of mTOR may provide more significant results in the treatment of GBM. In addition to new mTOR targets, which may have a plant origin form, more potent mTOR inhibitors by utilizing the computational methodology may emerge as a hope for GBM therapy. In the future, a better understanding of the functional properties of mTORC2 with its potent effective inhibitors may help design more efficiently GBM treatment modalities.

References

Jul 19, 2003·Genes & Development·Ken InokiKun-Liang Guan
Sep 26, 2003·Cancer Biology & Therapy·Monica M MitaEric K Rowinsky
Aug 18, 2004·Genes & Development·Nissim Hay, Nahum Sonenberg
Apr 30, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zelton Dave Sharp, Andrzej Bartke
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Zhaohui FengShengkan Jin
May 16, 2006·Cancer Cell·Qi-Wen FanWilliam A Weiss
May 26, 2006·Nature·Reuben J Shaw, Lewis C Cantley
Jul 7, 2007·Cancer Cell·David A Guertin, David M Sabatini
Oct 2, 2007·Trends in Molecular Medicine·Gary G Chiang, Robert T Abraham
Nov 3, 2007·Genes & Development·Frank B FurnariWebster K Cavenee
Feb 13, 2009·PLoS Biology·Morris E FeldmanKevan M Shokat
Apr 3, 2009·Nature Reviews. Molecular Cell Biology·Xiaoju Max Ma, John Blenis
Jul 30, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Debashis SarkerJohann S de Bono
Apr 29, 2010·The Journal of Clinical Investigation·Lucy R Osborne
May 18, 2010·Neuro-oncology·David AkhavanPaul S Mischel
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jérémie NeastaDorit Ron
Dec 16, 2010·Nature Reviews. Molecular Cell Biology·Roberto ZoncuDavid M Sabatini
Sep 6, 2011·Trends in Molecular Medicine·Peter B Crino
Apr 17, 2012·Cell·Mathieu Laplante, David M Sabatini
Jul 20, 2012·The Journal of Biological Chemistry·Malgorzata UrbanskaJacek Jaworski
Dec 13, 2012·Advances in Biological Regulation·Meena Jhanwar-UniyalRaj Murali
Jan 9, 2013·Anti-cancer Agents in Medicinal Chemistry·Deeba N SyedHasan Mukhtar
Feb 5, 2013·Bioorganic & Medicinal Chemistry Letters·Kurt G PikeMartin Pass
Feb 12, 2013·Biochimica Et Biophysica Acta·Michal Grzmil, Brian A Hemmings
Sep 14, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Beatrice GiniPaul S Mischel
Dec 25, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carlos Rodrigo Gil del AlcazarSandeep Burma
Feb 26, 2015·Cell Cycle·Tian Shao, Xiaoqi Liu

❮ Previous
Next ❯

Citations

Aug 29, 2016·Neurochemical Research·Ewelina Majewska, Monika Szeliga
Nov 5, 2016·Expert Opinion on Emerging Drugs·Julie J Miller, Patrick Y Wen
Dec 21, 2017·BioMed Research International·Silvia Anahi Valdés-RivesAliesha González-Arenas
Feb 23, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiang XuKannie W Y Chan
May 12, 2017·Frontiers in Cell and Developmental Biology·Marie Strickland, Elizabeth A Stoll
Apr 14, 2018·BioMed Research International·Fabliha Ahmed ChowdhuryMuhammad Shahdaat Bin Sayeed
Dec 21, 2016·Acta neurologica Belgica·Yu-Long LanBo Zhang
Feb 6, 2019·Biomolecules·Nadia R ZgajnarMario D Galigniana
Feb 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiao-Hui TanXiao-Li Xie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis