Role of mucin Lewis status in resistance to Helicobacter pylori infection in pediatric patients.

Helicobacter
Sara LindénAndre Dubois

Abstract

Helicobacter pylori causes gastritis, peptic ulcer and is a risk factor for adenocarcinoma and lymphoma of the stomach. Gastric mucins, carrying highly diverse carbohydrate structures, present functional binding sites for H. pylori and may play a role in pathogenesis. However, little information is available regarding gastric mucin in children with and without stomach diseases. Expression of mucins and glycosylation was studied by immunohistochemistry on gastric biopsies from 51 children with and without H. pylori infection and/or peptic ulcer disease. In all children, MUC5AC was present in the surface epithelium and MUC6 in the glands. No MUC6 in the surface epithelium or MUC2 was detected in any section. The Le(b) and Le(a) blood group antigens were present in the surface epithelium of 80% and 29% of children, respectively. H. pylori load was higher in Le(b) negative children than in Le(b) positive individuals (mean +/- SEM 17.8 +/- 3.5 vs 10.8 +/- 1.5; p < 0.05), but there was no correlation between Le(a) or Le(b) status and gastritis, nodularity, and gastric or duodenal ulcer (DU). Expression of sialyl-Le(x) was associated with H. pylori infection, and DU. Mucin expression and glycosylation is similar in children and adults...Continue Reading

References

Jan 1, 1995·Vox Sanguinis·S HenryB Samuelsson
Nov 21, 1998·Gut·M P BuisineJ P Aubert
Dec 16, 1998·Virchows Archiv : an International Journal of Pathology·H OtaR M Genta
Jan 19, 1999·JAMA : the Journal of the American Medical Association·S LevensteinA Dubois
Jul 9, 1999·Journal of Clinical Pathology·J C Bravo, P Correa
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·M GerhardC Prinz
Jul 15, 2000·Journal of Pediatric Gastroenterology and Nutrition·M C CohenR Drut
Nov 10, 2000·Annals of Diagnostic Pathology·A E WhitneyB D Gold
Dec 2, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M P BuisineN Porchet
May 8, 2002·São Paulo Medical Journal = Revista Paulista De Medicina·Luiz Carlos de MattosHaroldo Wilson Moreira
Dec 10, 2003·Journal of Clinical Microbiology·Mårten KiviMarta Granström
Jan 23, 2004·The Biochemical Journal·Sara LindénIngemar Carlstedt
Mar 31, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Yasser M El MiedanyHoussam Fahmy
Mar 3, 2006·Journal of Gastroenterology and Hepatology·Rong-Quan Wang, Dian-Chun Fang
Nov 28, 2007·Annual Review of Pathology·John C Atherton
Jan 9, 2008·PLoS Pathogens·Sara LindénAndre Dubois
Dec 30, 2009·Journal of Pediatric Gastroenterology and Nutrition·James R RickAndre Dubois

❮ Previous
Next ❯

Citations

Apr 12, 2012·Glycobiology·Lori Sc Kreisman, Brian A Cobb
Dec 3, 2014·Best Practice & Research. Clinical Gastroenterology·Doron Boltin, Yaron Niv
Sep 16, 2011·Helicobacter·Steffen Backert, Marguerite Clyne
Jan 22, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Cheng-Jiang ZhouYan-Bin Jia
May 15, 2012·Microbes and Infection·Sean O Ryan, Brian A Cobb
May 27, 2015·Nutrition Reviews·Devon KavanaughRita M Hickey
May 4, 2017·Molecular & Cellular Proteomics : MCP·Chunsheng JinNiclas G Karlsson
Jun 19, 2018·Microorganisms·Macarena P Quintana-HayashiSara K Lindén
Sep 3, 2016·The European Respiratory Journal·William J JanssenChristopher M Evans
Jun 25, 2016·Microscopy Research and Technique·Zelal KarakoçMuzaffer Aydın Ketani
Jul 12, 2017·World Journal of Gastroenterology : WJG·Shamshul Ansari, Yoshio Yamaoka
Apr 17, 2019·Infection and Immunity·Macarena P Quintana-HayashiSara Lindén
Mar 16, 2017·Molecular & Cellular Proteomics : MCP·Chunsheng JinNiclas G Karlsson
Jun 16, 2015·World Journal of Gastroenterology : WJG·Kathy Saraiva-PavaMónica Roxo-Rosa
Dec 17, 2020·Journal of Clinical Medicine·Ana-Maria Teodora DomșaCristina Maria Borzan
Oct 7, 2019·Biosensors & Bioelectronics·János Tamás PadraSara K Lindén
Feb 13, 2021·Annual Review of Immunology·Julie Y Zhou, Brian A Cobb
Sep 4, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Zelal KarakoçMuzaffer Aydın Ketani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.