Role of muscarinic M1 receptors in inhibitory avoidance and contextual fear conditioning

Neurobiology of Learning and Memory
Juliana Carlota Kramer SoaresMaria Gabriela Menezes Oliveira

Abstract

The objective of the present study was to observe the effects of pre-training or post-training administration of dicyclomine, a M1 muscarinic antagonist, on inhibitory avoidance (IA) and contextual fear conditioning (CFC) and to investigate if the effects observed with the pre-training administration of dicyclomine are state-dependent. For each behavioral procedure (IA and CFC) groups of Wistar male rats were treated with saline or dicyclomine either 30 min before training (pre-training), immediately after training or 30 min before training/30 min before test (pre-training/pre-test). The animals were tested 24 h after training. The acquisition of IA and CFC was impaired by pre-training administration of dicyclomine. The consolidation of both tasks was not affected by dicyclomine given immediately after training. Pre-training/pre-test administration of dicyclomine impaired both tasks, an effect similar to that observed in the group which only received pre-training administration. Pre-test treatment induced dissociation between both tasks, impairing CFC retrieval, without interfering with the animals avoidance response. These results show that the dicyclomine did not affect IA and CFC consolidation, suggesting specific involvemen...Continue Reading

Citations

Feb 22, 2011·Psychopharmacology·Inge Klinkenberg, Arjan Blokland
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Benoit PoulinAndrew B Tobin
Apr 24, 2008·Journal of Integrative Neuroscience·Thomas I NathanielFemi Olajuyigbe
Feb 18, 2012·Neuroscience Letters·Marina S ZacariasJosé C F Galduróz
Jan 25, 2011·Pharmacology, Biochemistry, and Behavior·Gary B Kaplan, Katherine A Moore
Apr 20, 2010·Neuroscience and Biobehavioral Reviews·Inge Klinkenberg, Arjan Blokland
May 2, 2014·Frontiers in Aging Neuroscience·Shogo SomaSatoshi Shimegi
Dec 6, 2016·Learning & Memory·Katherine LeaderbrandJelena Radulovic
Jun 26, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Maede RezaieMohammad Ali Nasiri Khalili
Oct 6, 2016·Journal of Neuroscience Research·Marlene A Wilson, Jim R Fadel
Dec 13, 2016·Physiology & Behavior·Rafael Rodisanski PatricioMaria Gabriela Menezes Oliveira
Jun 28, 2021·Neurobiology of Learning and Memory·Shogo SomaSatoshi Shimegi
Nov 6, 2020·Neuroscience Letters·Jean-Pascal MorinGabriel Roldán-Roldán

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