PMID: 11318978Apr 25, 2001Paper

Role of myofibroblasts in tumour encapsulation of hepatocellular carcinoma in haemochromatosis

Liver
K R BridleG A Ramm

Abstract

Hepatocellular carcinoma is a common malignancy and a major complication of untreated haemochromatosis. Encapsulation of liver tumours has been associated with a better prognosis and longer disease-free periods following resection. This study investigated the source of the tumour capsule in patients with haemochromatosis and coexisting hepatocellular carcinoma and examined potential factors influencing development. Five haemochromatosis patients with encapsulated hepatocellular carcinoma were studied. Myofibroblasts were identified using combined immunohistochemistry and in situ hybridisation for alpha-smooth muscle actin and procollagen alpha1(I) mRNA, respectively. Immunohistochemistry was also performed for transforming growth factor (TGF)-beta1, platelet-derived growth factor (PDGF)-beta receptor and malondialdehyde. Procollagen alpha1(I) mRNA co-localised to alpha-smooth muscle actin positive myofibroblasts. The number of myofibroblasts was maximal within the capsule and decreased away from the tumour. TGF-beta1 protein was expressed in iron-loaded cells in non-tumour liver at the interface of tumour capsule. PDGF-beta receptor expression was observed in mesenchymal cells in the tumour capsule and in portal tracts. Malondi...Continue Reading

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Citations

May 26, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Jie LiZhihai Qin
Mar 19, 2014·Advanced Drug Delivery Reviews·Claudio R ThomaWilhelm Krek
Jul 12, 2005·Expert Opinion on Investigational Drugs·Michael LahnBrandi S Berry
Dec 14, 2011·Journal of Surgical Oncology·Tsung-Han WuMiin-Fu Chen
Sep 19, 2006·Experimental and Molecular Pathology·Limei GuoMakoto Hiroi
Jul 4, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Alberto Bellini, Sabrina Mattoli
Dec 3, 2004·Cancer Research·Natalie C DirekzeNicholas A Wright
Nov 27, 2020·Frontiers in Cellular and Infection Microbiology·Hong Kiat LimCarolina Soekmadji

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